Preparation method of salazosulfapyridine

A technology of sulfasalazine and sulfadiazine, which is applied in the field of sulfasalazine, and can solve the problems of little disclosure of the preparation method

Inactive Publication Date: 2020-02-21
SUZHOU HUANGHE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the prior art, there are few disclosures on its preparation method

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  • Preparation method of salazosulfapyridine
  • Preparation method of salazosulfapyridine
  • Preparation method of salazosulfapyridine

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Embodiment Construction

[0030] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0031] Here, it should be noted that, in order to avoid obscuring the present invention due to unnecessary details, only the structures and / or processing steps closely related to the solution of the present invention are shown in the drawings, and the steps related to the present invention are omitted. Other details that don't really matter.

[0032] Additionally, it should be noted that the term "comprises", "comprises" or any other variation thereof is intended to cover a non-exclusive inclusion such that a process, method, article or apparatus comprising a set of elements includes not only those elements, but also Other elements not expressly listed, or inherent to the process, method, article, or apparatus are also included.

[0033] A kind o...

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Abstract

The invention provides a preparation method of salazosulfapyridine. The preparation method comprises the following steps: S1, carrying out a cyclic condensation reaction on sulfaguanidine serving as astarting raw material and a C3 active compound to obtain sulfadiazine; S2, dissolving the sulfadiazine obtained in the step S1 in an aqueous solution containing sodium nitrite for a diazotization reaction so as to further obtain a diazonium salt; and S3, transferring the diazonium salt obtained in the step S2 into an aqueous sodium hydroxide solution, and carrying out a coupling reaction with salicylic acid to finally obtain salazosulfapyridine. Aiming at the defects in the prior art, the invention provides the preparation method of salazosulfapyridine; and according to the preparation method, raw materials are easy to obtain, and the purity and yield of the obtained purified product are high.

Description

technical field [0001] The invention relates to the technical field of sulfasalazine, in particular to a preparation method of sulfasalazine. Background technique [0002] Sulfasalazine (SASP), also known as 5-[p-(2-pyridinesulfamoyl)benzene]azosalicylic acid. Molecular formula is C18H14N4O5S, molecular weight: 398.39. [0003] Sulfasalazine is an azo compound of salicylic acid and sulfapyridine, which has antibacterial, antirheumatic and immunosuppressive effects. In the intestinal tract, it is decomposed by the bacteria there into sulfapyridine (SP) and 5-aminosalicylic acid (5-ASA). [0004] SP has a weak antibacterial effect. It mainly acts as a carrier in the drug molecule, preventing the absorption of 5-ASA in the stomach and duodenum. Only under the alkaline condition of the intestinal tract, the intestinal microorganisms break the diazo bond and release active ingredients. Its mechanism is currently believed to be that 5-ASA complexes with the connective tissue o...

Claims

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Application Information

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IPC IPC(8): C07D213/76
CPCC07D213/76
Inventor肖祖华江尔胜
OwnerSUZHOU HUANGHE PHARMA CO LTD