White matter fiber bundle tracing analysis method and system based on magnetic resonance imaging

Abstract

The invention discloses a white matter fiber bundle tracing analysis method and system based on magnetic resonance imaging. The method comprises the following steps of 1) preprocessing a DTI image ofeach testee to obtain a fiber bundle direction distribution probability in each voxel in the whole brain of the corresponding testee; (2) converting a seed region in the standard space into a DTI space of each testee to serve as a seed ROI (region of interest); starting from each voxel of the seed ROI by adopting a plurality of streamlines, and extending according to the fiber bundle direction distribution probability in the voxel to obtain a probability connection map reflecting the seed region to the whole brain; reserving the voxels of which the connection probability with the seed ROI is greater than a set threshold value; (3) transforming the white matter fiber bundles in the DTI spaces of the testees into the standard MNI spaces, and (4) obtaining the standard fiber bundles which obviously exist in the DTI images of the testees according to the white matter fiber bundles of the testees in the standard MNI spaces. According to the present invention, the analysis accuracy is improved.

Description

technical field [0001] The invention relates to the field of medical image processing, in particular to a method and system for quantitatively analyzing white matter fiber bundles by processing magnetic resonance brain images. Background technique [0002] Diffusion Tensor Imaging (DTI for short), also commonly known as Diffusion Tensor Imaging in clinical practice (Icank Basser P J, Pajevic S, Pierpaoli C, et al. In vivo fibertractography using DT-MRI data[J]. Magn Reson Med, 2000, 44(4):625-632). DTI indirectly observes the microstructural properties of white matter tissue by measuring the degree and direction of water molecule diffusion in the tissue. DTI imaging technology is currently the only technology that can non-destructively display the direction of the nerve fiber bundles of the white matter of the brain in vivo, and is widely used in clinical and human brain science research. [0003] Tractography or fiber tracking is a technique for imaging fiber tracts. The...

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Problems solved by technology

However, this algorithm also has its inherent defects: the algorithm believes that there is only one direction of the fiber bundle in an anisotropic voxel, that is, the principal vector direction

[0007] (1) Existing fiber tract tracing, whether deterministic or probabilistic, occurs in the individual space of the subject, and there is no satisfactory registration method, and brain science often needs to be studied in a standard space

[0008] (2) Since the shape of the fiber tracts connecting the same brain area varies greatly among different individuals (this is normal and reflects the uniqueness of human connectomics and individual cognition), the fibers obtained in different subjects Beam Tracing Results Difficult for Group Analysis

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