A kind of seaweed functional oil and its application
A seaweed and functional technology, which is applied to seaweed functional oil and its application field, can solve the problems of less research, difference in active ingredient content, difference in extraction results, etc., and achieves the effects of high activity, simple method and low cost.
Active Publication Date: 2022-01-07
SHENZHEN INST OF GUANGDONG OCEAN UNIV +1
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Problems solved by technology
Studies have shown (Zhang Yi et al., 2005, research on the inhibition of acetylcholinesterase activity by seaweed components), some types of seaweed components have the activity of inhibiting acetylcholinesterase; but the active ingredient content of different algae is significantly different, and there are few related studies at present The extraction results of different algae-related active ingredients by different extraction processes also show great differences
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Embodiment 1
[0038] The preparation of embodiment 1 seaweed functional oil
[0039] 1. Experimental method
[0040] 1, a kind of seaweed functional oil, its preparation method comprises the following steps:
[0041] S1. Remove impurities from the purchased or collected seaweed Hijiki, put it in a 40°C oven for 1 hour or dry it in a 40°C oven for 1 hour, grind it with a pulverizer, and add methanol twice its volume: chloroform= 1:2 Soaking overnight, suction filtration, concentration under reduced pressure, repeated 3 times to obtain the crude extract of seaweed Hijiki;
[0042] S2. Pass the crude extract of Sargassum sargassum obtained in step S1 through a decompression column (the packing of the decompression column is silica gel of 100-200 meshes), and elute and separate with the following reagents respectively:
[0043] (1) Elute and separate with petroleum ether: ethyl acetate (volume ratio) = 8:2, 7:3, 1:1, 3:7 to obtain 4 crude components Fr1-Fr4;
[0044] (2) eluted and separated...
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The invention discloses a seaweed functional oil and its application. The present invention firstly provides a seaweed functional oil. The seaweed functional oil is firstly eluted with a mixed solution of petroleum ether and ethyl acetate, and then washed with a mixed solution of petroleum ether, chloroform and methanol. After removal, the active components satisfying the ratio shift value of thin-layer chromatography of 0.1 to 0.4 and the autoimage of acetylcholinesterase as white spots are collected to obtain the seaweed functional oil. The seaweed functional oil has a significant activity of inhibiting acetylcholinesterase, scavenging DPPH free radicals, inhibiting the generation of NO induced by intracellular inflammatory factors, and scavenging the ROS level in cells, and has no toxic side effects on normal cells; in addition , the preparation method has high yield, natural material sources, the obtained seaweed functional oil is non-toxic, does not cause adverse reactions, and has good application prospects in the preparation of drugs for treating Alzheimer's disease.
Description
technical field [0001] The invention belongs to the technical field of essential oil extraction. More specifically, it relates to a seaweed functional oil and its application. Background technique [0002] Alzheimer's disease (AD), commonly known as senile dementia, is one of the major diseases that endanger human health in the 21st century. It is a neurodegenerative disease accompanied by cognitive, behavioral and functional disorders. older people. Existing studies have shown that AD is closely related to oxidative stress in the brain, neurodegeneration caused by neuroinflammation, and cholinergic neuron damage. According to the 2016 World AD Report, the number of people suffering from AD in that year was as high as 47 million, and with the acceleration of population aging, the number of AD patients in my country is increasing at the fastest rate in the world. Experts predict that by 2025 the world will have 22 million people suffer from AD. At the same time, AD patient...
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IPC IPC(8): C07C51/42C07C53/126C07C57/03C07C29/74C07C33/03A61K36/03A61P25/28A61P39/06A61P29/00A23L33/10
CPCC07C51/42C07C29/74A61K36/03A61P25/28A23L33/10A23V2002/00A23V2200/322A23V2250/202C07C53/126C07C57/03C07C33/03
Inventor 张翼杨文聪张嫄嫄千忠吉李亚娟刘亚月杨静明聂影影宋采梁金月马小翔刘敬珊刁慧雯
Owner SHENZHEN INST OF GUANGDONG OCEAN UNIV