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Barbituric acid derivative modified molybdenum disulfide two-dimensional nano material and application thereof

A two-dimensional nanomaterial, molybdenum disulfide technology, applied in the direction of molybdenum sulfide, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc.

Active Publication Date: 2020-03-06
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, after searching, there are reports on the synthesis of molybdenum disulfide two-dimensional nanomaterials modified by thiobarbituric acid derivatives with diverse hydrophilic and hydrophobic properties and charges and their applications in the preparation of anti-tumor drugs and nano-loaded drugs. Patents and related literature have not yet been reported

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  • Barbituric acid derivative modified molybdenum disulfide two-dimensional nano material and application thereof
  • Barbituric acid derivative modified molybdenum disulfide two-dimensional nano material and application thereof
  • Barbituric acid derivative modified molybdenum disulfide two-dimensional nano material and application thereof

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Embodiment 1

[0054] Embodiment 1 Ligand 2-thiobarbituric acid, molybdenum disulfide nanomaterial (MoS 2 -1) Synthesis

[0055] Two-dimensional molybdenum disulfide nanomaterials (MoS) modified with 2-thiobarbituric acid, benzoic acid (Ligand1) 2 -1) As an example, the synthesis of the two-dimensional molybdenum disulfide nanomaterial modified by barbituric acid derivatives described in the present invention is described.

[0056] The reaction formula involved in the specific reaction pathway is as follows:

[0057]

[0058] (1) Molybdenum disulfide (4.8 g, 0.03 mol) was mixed with 30 mL of N,N-dimethylformamide (DMF) in an ice bath, and stirred evenly. Under vigorous stirring, 2-thiobarbituric acid (7.0 g, 0.06 mol) was thus added to the above reaction system. React under ice bath for 4-6 hours, heat and reflux for 4-6 hours, after the reaction, sonicate at 290K for 120 hours to obtain a suspension of the intermediate product (1).

[0059] (2) Under ice bath, mix and dissolve benzoi...

Embodiment 2

[0061] Example 2 For 2-thiobarbituric acid, the two-dimensional molybdenum disulfide nanomaterial (MoS) modified by cyclohexyl formic acid (Ligand2) 2 -2) Synthesis

[0062] The preparation method is similar to that of MoS in Example 1 2 -1 preparation, the difference is that the 6.1g benzoic acid used in step b is replaced by 6.4g cyclohexyl formic acid to finally obtain the DMF solution of cyclohexyl formic acid-N-hydroxysuccinimide active ester; The benzoic acid-N-hydroxysuccinimide active ester was replaced by the cyclohexylcarboxylic acid-N-hydroxysuccinimide active ester.

Embodiment 3

[0063] Example 3 For 2-thiobarbituric acid, n-heptanoic acid (Ligand3) modified two-dimensional molybdenum disulfide nanomaterials (MoS 2 -3) Synthesis

[0064] The preparation method is similar to that of MoS in Example 1 2-1, the difference is that the 6.1g benzoic acid used in step b is replaced by 6.5g n-heptanoic acid to finally obtain the DMF solution of n-heptanoic acid-N-hydroxysuccinimide active ester; The benzoic acid-N-hydroxysuccinimide active ester was replaced by n-heptanoic acid-N-hydroxysuccinimide active ester.

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Abstract

The invention discloses a thiobarbituric acid derivative molecule modified molybdenum disulfide two-dimensional nano material with diversified hydrophilic and hydrophobic properties and charges, whichis a molybdenum disulfide nano material respectively modified by Ligand 1-Ligand 9 ligand molecular compounds shown as formulas (I) to (IX), and is sequentially named as MoS2 <-1>-MoS2 <-9>. The invention also discloses an application of the molybdenum disulfide nano material in preparation of drugs and drug carriers for inhibiting tumor cell growth, or in preparation of paclitaxel-loaded drug complexes for inhibiting tumor cell growth as a drug carrier. The experiments prove that the thiobarbituric acid derivative molecule modified molybdenum disulfide two-dimensional nano material with diversified hydrophilic and hydrophobic properties and charges is expected to become a potential drug or drug carrier for tumor synergistic treatment, and has broad scientific research and clinical application prospects.

Description

technical field [0001] The invention relates to a class of two-dimensional molybdenum disulfide nanomaterials and applications thereof, in particular to a class of molecularly modified molybdenum disulfide two-dimensional nanomaterials and their The invention belongs to the field of surface functionalized modified nanometer material and its application. Background technique [0002] With the development of nanotechnology, engineered nanoparticles have a wide range of applications in production, life and nanomedicine. The tiny size of nanoparticles makes them useful in biomedicine due to their ability to penetrate tissues, including lymph, and be subsequently phagocytized by effector cells. Nanoparticles have been realized to be very useful and may bring unexpected effects in various medical applications ranging from disease diagnosis to disease treatment. Among them, two-dimensional nanomaterials have begun to be widely used in the field of biomedicine due to their favorab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K47/22A61K47/14A61K47/10A61K47/24A61K47/18A61K33/04A61K31/337A61P35/00C01G39/06
CPCA61K31/337A61K33/04A61K47/02A61K47/10A61K47/14A61K47/18A61K47/22A61K47/24A61P35/00C01G39/06A61K2300/00
Inventor 翟淑梅王小玲闫兵王深清江翠娟
Owner SHANDONG UNIV
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