A kind of natural composition for lowering uric acid and its application and xanthine oxidase inhibitor
A xanthine oxidase and composition technology, which is applied in the field of xanthine oxidase inhibitors, can solve problems such as differences, unclear compound composition mechanism, unclear individual efficacy of raw materials, etc.
Active Publication Date: 2021-12-03
SYI BIOTECH CO LTD
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Problems solved by technology
[0009] Relevant literature shows that most of the compound prescriptions that use natural products to lower uric acid or treat gout are traditional Chinese medicine compound prescriptions. The selection and preparation of raw materials are not easy and complicated, and the individual efficacy of the raw materials in the compound prescriptions is unknown, and it is not known that the composition ratio of the compound prescriptions is relatively large. What are the differences in their efficacy, and the mechanism of the compound ingredients is not clear
Method used
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Experimental program
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Effect test
Embodiment 1
[0033] In order to clarify the inhibitory effect of each natural product on xanthine oxidase alone and in combination in various proportions, firstly, the natural product was obtained and extracted and hydrolyzed. The natural products are soil cinnamon from Taiwan, China, which is a unique species in Taiwan, China, and dried licorice and guava from the Chinese herbal medicine industry.
[0034] During implementation, the specific operation of the extraction project is as follows:
[0035] Weigh the dried soil cinnamon, licorice, and guava respectively, 100 grams (g) each, add 1.0 liter (L) of 50% ethanol, extract at 50°C for 4 hours, remove the filter residue by filtration, concentrate the filtrate in vacuum and freeze After drying, a powdered extract is obtained.
[0036] During implementation, the specific operation of the hydrolysis project is as follows:
[0037]After accurately weighing 20 milligrams (mg) of soil cinnamon, licorice, and guava dried extracts, add 8 milli...
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The invention discloses a natural composition for lowering uric acid, its application and a xanthine oxidase inhibitor. The natural composition comprises soil cinnamon, licorice, and dried guava, wherein the soil cinnamon, licorice, and guava The stems are processed by hydrolysis engineering without adding enzymes or ethyl acetate. The natural composition can be further added with pharmaceutically acceptable carriers, excipients, diluents, or anti-inflammatory agents, or combined with other ingredients for Combination of health food or medicine related to lowering uric acid; the natural composition can be used as a xanthine oxidase inhibitor, or used to prepare a pharmaceutical composition for improving hyperuric acid-related diseases or to prepare a medicine for diseases using a xanthine oxidase inhibitor Pharmaceutical composition.
Description
technical field [0001] The invention relates to the field of natural compositions, in particular to a natural composition for lowering uric acid, its application and a xanthine oxidase inhibitor. Background technique [0002] Uric acid (uric acid) is the final metabolite of purines produced by xanthine oxidase through layers of enzymes in the human body. When the environment, genetics or living habits affect the reduction of uric acid excretion or excessive production of uric acid, it will form in the blood. The state of high uric acid, known as hyperuricemia, is often complicated by other diseases, such as: gout, recurrent gout attacks, gouty arthritis, kidney disease, kidney stones, kidney failure, joint inflammation, arthritis, and Urolithiasis, etc. Gout is the representative complication among them. It is an inflammatory disease caused by the deposition of sodium urate, which will cause inconvenience to the patient's activities and often cause great inconvenience to the...
Claims
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IPC IPC(8): A61K36/61A61P19/06A61P13/12A61P13/04A61P19/02A61P29/00
CPCA61K36/484A61K36/54A61K36/61A61K2236/333A61K2236/51A61P13/04A61P13/12A61P19/02A61P19/06A61P29/00A61K2300/00
Inventor 连秀屘陈家章张筱君曾景瑞
Owner SYI BIOTECH CO LTD