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Special nano-silver sol for gel and preparation method thereof

A technology of nano-silver sol and gel, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., and can solve the problems of unfavorable nano-silver antibacterial gel, nano-silver particle agglomeration, discoloration, etc. problem, to achieve the effect of good system stability

Inactive Publication Date: 2020-03-31
ZHANGJIAGANG NELLNANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the nano-silver solutions on the market often adopt a unique stabilization system, they are relatively stable in their respective stabilization systems, but when they are added to the carbomer gel, the stabilization system is changed or destroyed, resulting in the agglomeration of nano-silver particles, Discoloration, etc., is not conducive to obtaining a stable and uniform nano-silver antibacterial gel
Therefore, for the lack of compatibility and stability of existing nano-silver sol and carbomer gel, it is necessary to find a special nano-silver sol for gel with good carbomer compatibility and its preparation method to meet the needs of nano-silver gel. The processing needs of antibacterial gel

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] (1) Weigh 0.1 carbomer and dissolve it in 1 liter of deionized water, add an appropriate amount of triethanolamine solution, adjust the pH value to neutral, and obtain a neutral carbomer solution with a mass concentration of 0.g / l;

[0015] (2) Weigh 3.13g of silver nitrate and dissolve it in 1l of deionized water to obtain a silver salt solution with a mass concentration of 3.13g / l; dissolve sodium borohydride in deionized water to obtain a mass concentration of 0.13g / l sodium borohydride aqueous solution;

[0016] (3) Mix the neutral carbomer solution and silver salt solution 1:1, and stir evenly. Under constant stirring, add sodium borohydride aqueous solution dropwise until the silver ions are completely reduced to nano-silver particles, that is, the silver content is about 1000mg / kg special nano-silver sol for gel.

[0017] Add this nano-silver antibacterial gel to the carbomer gel with a solid content of 0.2% at a ratio of 1:5 to obtain a stable and uniformly dis...

Embodiment 2

[0019] (1) Weigh 0.1 carbomer and dissolve it in 1 liter of deionized water, add an appropriate amount of diethanolamine solution, adjust the pH value to neutral, and obtain a neutral carbomer solution with a mass concentration of 0.g / l;

[0020] (2) Weigh 3.09g of silver acetate and dissolve it in 1l of deionized water to obtain a silver salt solution with a mass concentration of 3.09g / l; dissolve sodium borohydride in deionized water to obtain a mass concentration of 0.13g / l sodium borohydride aqueous solution;

[0021] (3) Mix the neutral carbomer solution and silver salt solution 1:1, and stir evenly. Under constant stirring, add sodium borohydride aqueous solution dropwise until the silver ions are completely reduced to nano-silver particles, that is, the silver content is about 1000mg / kg special nano-silver sol for gel.

[0022] Add this nano-silver antibacterial gel to the carbomer gel with a solid content of 0.2% at a ratio of 1:5 to obtain a stable and uniformly disp...

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PUM

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Abstract

The invention discloses special nano-silver sol for gel and a preparation method thereof. The special nano-silver sol for gel is prepared through the following steps that carbomer is dissolved in deionized water, a proper amount of an alkaline solution is added, the pH value is adjusted to be neutral, and a neutral carbomer solution with the mass concentration of 0.01-2 g / l is obtained; silver salt is dissolved in deionized water to obtain a silver salt aqueous solution with the mass concentration of 0.001-10g / l; sodium borohydride is dissolved in deionized water to obtain a sodium borohydrideaqueous solution with the mass concentration of 0.001-1g / l; the neutral carbomer solution is mixed with the silver salt aqueous solution, uniform stirring is carried out, and the sodium borohydride aqueous solution is subjected to dropwise adding during continuous stirring until silver ions are completely reduced into nano-silver particles, thereby the special nano-silver sol for gel is obtained.The nano-silver sol system disclosed by the invention is good in stability, can be directly added into carbomer gel, and is convenient to popularize and apply in nano-silver antibacterial gel.

Description

technical field [0001] The invention relates to the field of nano silver sol, in particular to a special nano silver sol for gel and a preparation method thereof. Background technique [0002] Nano-silver has strong antibacterial and bactericidal effects and broad-spectrum antibacterial activity. Due to the quantum effect, small size effect and large specific surface area, it has an antibacterial effect that cannot be compared with traditional inorganic antibacterial agents. In gynecological diseases and burn wound medicine, nano-silver antibacterial gel has been widely used clinically. The preparation of nano-silver antibacterial gel is usually to add nano-silver solution to carbomer aqueous solution, and then adjust the pH value to neutral to obtain antibacterial gel. Because the nano-silver solutions on the market often adopt a unique stabilization system, they are relatively stable in their respective stabilization systems, but when they are added to the carbomer gel, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/32A61K33/38A61P31/04
CPCA61K9/06A61K33/38A61K47/32A61P31/04
Inventor 张峰
Owner ZHANGJIAGANG NELLNANO TECH