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Pharmaceutical composition for treating tumors

A drug and tumor technology, applied in the field of biomedicine, can solve problems such as tissue cytotoxicity

Pending Publication Date: 2020-03-31
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chemotherapy drugs not only have a killing effect on tumor cells, but also have toxicity to normal tissue cells in the body

Method used

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  • Pharmaceutical composition for treating tumors
  • Pharmaceutical composition for treating tumors
  • Pharmaceutical composition for treating tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1, DHCP and TRAIL can jointly inhibit the growth of colon cancer cells and colon cancer

[0047] 1. Experimental materials

[0048] Human colon cancer cells HCT116 and HT-29 are ATCC products.

[0049] BALB / cA-nu Mice is a product of Beijing Huafukang Biotechnology Co., Ltd.

[0050] TRAIL: It is an abcam product, item number ab109360.

[0051] DHCP specific preparation method reference (Akimoto-Tomiyama et al., Production of 5'-phosphodiesterase by Catharanthus roseus cells promoted by heat-degraded products generated from uronic acid, J Biosci Bioeng.2002; 94 (2): 154-9) ,Proceed as follows:

[0052] 1. Preparation of DHCP

[0053] Weigh 4g of galacturonic acid (Sigma Aldrich, product number 92478), add 800mL of distilled water, stir to dissolve, put the obtained sample solution in a sterilizing pot, 121 ° C, 17.2-21.7psi (0.12MPa) high temperature treatment 4 times, 1 hour each time, cooled to room temperature, filtered, and freeze-dried to obtain DHCP. ...

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Abstract

The invention discloses a pharmaceutical composition for treating tumors. The disclosed pharmaceutical composition for treating tumors comprises DHCP and TRAIL. Experiments prove that the DHCP and theTRAIL are combined together to inhibit the growth of tumor cells, thereby promoting the apoptosis of the tumor cells and further inhibiting the growth of tumors. The effects of the DHCP and the TRAILare obviously higher than those of the DHCP and the TRAIL which are independently used, so that the DHCP and the TRAIL can be used for treating the tumors. The pharmaceutical composition has the broad application prospects.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating tumors in the field of biomedicine. Background technique [0002] Colon cancer is a highly lethal malignancy worldwide. Currently, the treatment methods for colorectal cancer mainly include surgical resection, radiotherapy, chemotherapy, and targeted therapy using angiogenesis inhibitors and epidermal growth factor receptor inhibitors. However, colon cancers differ in molecular characteristics, response to radiotherapy and chemotherapy, clinical manifestations, and prognosis of the disease. Therefore, there is an urgent need to develop effective treatments. [0003] Human tumor necrosis factor-related apoptosis-inducing ligand TRAIL (TNF Related Apoptosis Inducing Ligand) is a member of the tumor necrosis factor superfamily. TRAIL can specifically kill tumor cells by binding to death receptors on the surface of cell membranes and transmitting apoptosis signals into cells. The select...

Claims

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Application Information

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IPC IPC(8): A61K38/19A61K31/122A61P35/00A61P1/00
CPCA61K38/191A61K31/122A61P35/00A61P1/00A61K2300/00
Inventor 程海荣周义发陈磊台桂花
Owner NORTHEAST NORMAL UNIVERSITY