A kind of method for decomposing triazine ring residue and recovering methylhydrazine

Abstract

The invention discloses a method for decomposing and recovering methylhydrazine residues of triazine rings. Adding residues of triazine rings, water and copper salt into a reaction bottle, starting stirring, raising the temperature to 80-130°C for 2-5 hours, and following the reaction Carry out, extract distillate fraction from reaction bottle, distill distillate after distillate adds alkali, distill out composition and be the mixture of methylhydrazine and water. The present invention hydrolyzes the by-product triazine ring residue to recover methylhydrazine and is used for the synthesis of 2-methylthiosemicarbazide, further synthesizing the triazine ring, utilizing waste resources, solving the problem that the industrialization of the triazine ring residue is difficult to handle, and realizing The triazine ring residue is recycled to methylhydrazine and then to the triazine ring. No solvent is used, which eliminates the disadvantages of flammability, explosion and high cost of organic solvents; the raw material is only the triazine ring residue reacts with water, and the copper salt is used as a catalyst to recover and produce methylhydrazine, and hydrolyze the triazine ring residue into small Molecular salt, easy to handle, safe and environmentally friendly, low cost, suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of recycling and utilization of by-products of pharmaceutical intermediates, and in particular relates to a method for decomposing and recovering methylhydrazine from triazine ring residues. Background technique [0002] Methylhydrazine is an important raw material for the synthesis of 2-methylthiosemicarbazide, and 2-methylthiosemicarbazide is further reacted with diethyl oxalate to synthesize triazine ring. The triazine ring is a key intermediate in the synthesis of ceftriaxone sodium, and after synthesizing 7-ACT (7-amino ceftriaxone) with 7-ACA (7-amino cephalosporanic acid), and then with DAMA to synthesize ceftriaxone sodium . Ceftriaxone sodium, also known as ceftriaxone, is a landmark third-generation cephalosporin antibiotic developed by Roche, Switzerland. , mainly used for infectious diseases caused by sensitive bacteria, such as respiratory system infections (especially pneumonia), ENT infections, urinar...

AI Technical Summary

Problems solved by technology

[0003] At present, the main problem of the triazine ring in the industrial production process is the low yield of the product, and the yield of the triazine ring can reach 71%. The yield is not high, and the amount of by-products produced during the synthesis process is large and difficult to handle. Under the tense environmental protection situation, it is imperative to effectively recycle and treat triazine ring residues

Images