Free radical cyclization reaction method of 1,6-eneyne compound and ether compound

A technology of ether compounds and cyclization reaction, applied in the direction of organic chemistry, etc., can solve the problems of limiting the diversity of organic molecules, and achieve the effect of adapting to a wide range
CN110950850AActive Publication Date: 2020-04-03NINGBO UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NINGBO UNIV
Publication Date
2020-04-03

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Abstract

The invention relates to a regioselective free radical cyclization reaction method of a 1,6-eneyne compound and an ether compound in a transition-metal-free catalyst system. The method comprises the following steps: adding a 1,6-enyne compound, an ether compound, an alkali additive and an oxidizing agent into a Schlenk reaction bottle, and carrying out a stirring reaction at a certain temperatureunder an air atmosphere condition to obtain a cyclization product 2-pyrrolidone compound.
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Description

technical field

[0001] The application belongs to the field of organic synthesis, and specifically relates to a regioselective free radical cyclization reaction method of 1,6-enynes and (thio)ether compounds without a transition metal catalyst system. Background technique

[0002] α-functionalized ether derivatives are widely found in medicines, natural products and agrochemicals, exhibiting a variety of biological activities. Formula 1 is a representative α-functionalized ether derivative with biological activity. Therefore, it is imminent to prepare this kind of skeleton through the α-C-H functionalization reaction of cheap and easy-to-obtain ether compounds. In recent years, chemists have developed functional group reactions of ether compounds with ketones, carboxylic acids, amines, aromatics, heteroaromatics, alkenes, alkynes, and enyne derivatives. Among them, the reaction between ether compounds and enyne derivatives has attracted much attention. On the one hand, it i...

Claims

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