Antibiotic bone cement for treating orthopedic infection

A technology of antibiotics and bone cement, applied in medical science, surgical adhesives, applications, etc., can solve the problems of decreased anti-infection ability of antibiotics, inconvenient antibiotic release, poor mechanical properties, etc., to improve anti-infection ability and reduce drug resistance , enhance the effect of mechanical properties

Inactive Publication Date: 2020-04-10
苏州众泽医疗科技有限公司
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Problems solved by technology

[0002] Bone cement is a common name for bone cement. Bone cement is a medical material used in orthopedic surgery. Antibiotic cement is to add antibiotics to bone cement to prevent and treat infection after artificial joint replacement. When the existing antibiotic bone cement is used, the antibiotic bone cement may have excellent mechanical properties when used, but it is not convenient for the release of antibiotics, o

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  • Antibiotic bone cement for treating orthopedic infection

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Embodiment 1

[0022] An antibiotic bone cement for the treatment of orthopedic infections, the main components of the antibiotic bone cement for the treatment of orthopedic infections: polymethyl methacrylate, vancomycin, tobramycin and dextran, the proportion of the main components It is polymethyl methacrylate 82%, vancomycin 8%, tobramycin 8%, dextran 2%.

[0023] Further, the monomer of the polymethyl methacrylate is methyl methacrylate, the density of the polymethyl methacrylate is lower than that of glass, the mechanical strength is higher, the melting point is lower, and the light transmittance is higher. Related properties of polymethyl methacrylate.

[0024] Further, the vancomycin is resistant to methicillin-sensitive and drug-resistant strains in Staphylococcus, including Staphylococcus aureus and coagulase-negative Staphylococcus, various streptococci, Streptococcus pneumoniae and most Gram-positive bacteria such as Enterococcus. It has good antibacterial effect, and expounds t...

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Abstract

The invention discloses antibiotic bone cement for treating orthopedic infection. The antibiotic bone cement for treating orthopedic infection comprises the following main components: polymethyl methacrylate, vancomycin, tobramycin and dextran. According to the invention, the dextran is added into original polymethyl methacrylate, so cavitation bubbles in a cured product are increased, and the release of antibiotics can also be promoted, while mechanical properties are reduced; by adoption of vacuum stirring, bubbles are reduced, while mechanical properties of the bone cement can be reinforced; by combination of vacuum stirring with the dextran, the effect that the mechanical properties and the antibiotic release rate are relatively moderate can be achieved; moreover, by addition of the vancomycin and the tobramycin at two sides respectively, releasing of antibiotics at a using position through mutual cooperation of two antibiotics can be realized, and the anti-infection capacity is improved; meanwhile, by combined application of two antibiotics, the antibacterial spectrum is expanded, and drug resistance is reduced; and certain using prospects are achieved.

Description

technical field [0001] The invention relates to the field of antibiotic bone cement, in particular to an antibiotic bone cement for treating orthopedic infection. Background technique [0002] Bone cement is a common name for bone cement. Bone cement is a medical material used in orthopedic surgery. Antibiotic cement is to add antibiotics to bone cement to prevent and treat infection after artificial joint replacement. When the existing antibiotic bone cement is used, the antibiotic bone cement may have excellent mechanical properties when used, but it is not convenient for the release of antibiotics, or the antibiotic release is excellent, but its own mechanical properties are poor, and the use can be improved by adding a single antibiotic. Anti-infection ability, but the bacteria have certain drug resistance, so a single antibiotic is used for a long time and the anti-infection ability is reduced, and the infection is easy. Therefore, we propose an antibiotic bone cement f...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/06
CPCA61L24/00A61L24/001A61L24/0015A61L24/06A61L2300/406A61L2300/45A61L2300/602C08L33/12
Inventor 朱贞艳李郃朱建民
Owner 苏州众泽医疗科技有限公司
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