A kind of medicine for treating brain glioma and preparation method thereof

A technology of pharmacy and compound, applied in the field of pharmacy, can solve the problem of small dosage and so on
CN110981865BActive Publication Date: 2021-01-12JIAMUSI UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIAMUSI UNIVERSITY
Publication Date
2021-01-12

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Abstract

The present invention relates to a compound containing benzodioxane and thiazole and a pharmaceutically acceptable salt, a preparation method and application thereof. The structure of the compound isrepresented by a formula I, wherein R is selected from hydrogen, C1-C5 alkyl, C1-C5 alkoxy, halogen or COORE and RE is selected from C1-C5 alkyl. The compound has the advantages that the treatment effect on the brain glioma is obviously improved, the dosage is small, the toxicity to normal tissue cells is avoided, the water solubility is also greatly improved in comparison with that of the compound and the compound has great application prospects in the treatment of tumor diseases, particularly the brain glioma.
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Description

technical field

[0001] The invention relates to the field of pharmacy, in particular to a compound containing benzodioxane and thiazole, a preparation method, and an application thereof for preparing a medicine for treating glioma. Background technique

[0002] Glioma is the most common intracranial malignant primary brain tumor, which accounts for 80% of brain malignant tumors. Infiltrative growth is the characteristic of glioma, so the tumor tissue is unclear, making it impossible to completely treat it through surgery. It is very difficult to remove the diseased tissue, so glioma is very easy to relapse after resection. The World Health Organization (WHO) classification of tumors of the central nervous system divides brain gliomas into grades I to IV. Gliomas are grade I. For example, pilocytic tumors are very slow-growing tumors. If this type of tumor is completely resected, Patients may be cured. Glioma grade II (common oligoastrocytoma, astrocytoma, etc.), aggressive...

Claims

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