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Single flowing particle detection method and system based on laser self-mixing feedback interference

A detection system and detection method technology, applied in individual particle analysis, biological particle analysis, particle and sedimentation analysis, etc., can solve the problem of failure to reveal the application of laser self-mixing interference signals, failure to reveal judgment parameters, failure to reveal single particles, etc. problem, to achieve the effect of reducing complexity and cost, simple structure and low price

Active Publication Date: 2020-04-10
BEIJING UNIV OF TECH
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Problems solved by technology

It is essentially equivalent to the overall sample detection statistical method mentioned above, and the detection of individual particles and particle groups in this field belongs to different research fields, such as the selection of detection principles, the control of single-cell flow, and the determination of parameters. There are large differences in selection and other aspects, and it is difficult for those skilled in the art to learn from each other
In addition, because the whole particle group is detected in Document 2, it fails to reveal whether the laser self-mixing interference signal can be applied to the detection of a single particle, nor does it reveal which judgment parameters to choose and what processing to do with the judgment parameters to implement a single Particle detection, more does not reveal how to identify individual particles as the target particles for the intended detection

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  • Single flowing particle detection method and system based on laser self-mixing feedback interference
  • Single flowing particle detection method and system based on laser self-mixing feedback interference
  • Single flowing particle detection method and system based on laser self-mixing feedback interference

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Embodiment Construction

[0051] The present invention is based on the principle of laser self-mixing feedback interference effect. When the laser beam is irradiated on a moving object, after the laser beam is reflected or scattered by an external object, part of the information carried by the laser is collected back into the laser cavity and combined with the information in the cavity. The mixed interference of the laser causes the output light intensity and frequency of the laser to change. By measuring the laser output power or the change of the node current, the displacement and speed of the object can be measured.

[0052] In order to make the above objects, features and advantages of the present invention more comprehensible, specific embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0053] See attached figure 1 , is a schematic diagram of the structure of the single flow particle detection system of the present invention; im...

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Abstract

The invention provides a single flowing particle detection method and system based on a laser self-mixing feedback interference technology. Scattered feedback light formed after laser irradiates the detection sample particles is collected into the laser cavity again to form mixed interference light with intrinsic light in the cavity, then mixed interference light is collected, the average signal frequency spectrum is calculated, Doppler frequency shift signal distribution on the self-mixed interference signal frequency spectrum is observed and compared with a preset theoretical value, and thenwhether a single expected type of flowing particles are detected or not is determined.

Description

technical field [0001] The invention relates to the technical field of single particle detection, in particular to a photoelectric detection method and system for real-time and accurate detection of single particles such as biological cells or antigenic substances based on the self-mixing (feedback) interference effect of semiconductor lasers. Background technique [0002] The detection of single particles (such as cells, antigenic substances, etc.) is widely used in the field of biomedicine. The measurement and analysis of individual sample cells one by one is more accurate than the overall detection statistics of the sample, and the required sample cell count is smaller, which is the current mainstream research direction. [0003] In the prior art, the single particle detection technology mainly includes: [0004] It is like fluorescence scattering flow cytometry, which mainly uses particle scattering principle and fluorescence detection technology for cell identification...

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Application Information

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IPC IPC(8): G01N15/14G01N15/00
CPCG01N15/1434G01N15/00G01N15/01
Inventor 赵宇张晨陈涛
Owner BEIJING UNIV OF TECH
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