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Cetylpyridinium chloride buccal tablet and preparation technology thereof

A cetylpyridinium chloride, preparation process technology, applied in the direction of medical preparations containing active ingredients, medical preparations without active ingredients, pill delivery, etc., can solve the problems of complicated preparation process, and achieve easy preparation process and high product quality Stable and reliable, the effect of improving medication compliance

Pending Publication Date: 2020-04-14
四川健能制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are many types of auxiliary materials for the above-mentioned cetylpyridinium chloride buccal tablets, and the preparation process is relatively complicated.

Method used

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  • Cetylpyridinium chloride buccal tablet and preparation technology thereof
  • Cetylpyridinium chloride buccal tablet and preparation technology thereof
  • Cetylpyridinium chloride buccal tablet and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]

[0028] Preparation Process:

[0029] 1) Pretreatment of raw and auxiliary materials: Cetylpyridinium chloride, xanthan gum, and mannitol are passed through a 80-mesh sieve, and magnesium stearate is passed through a 100-mesh sieve.

[0030] 2) Weighing: Take cetylpyridinium chloride, xanthan gum, mannitol and magnesium stearate according to the prescription.

[0031] 3) Total blending: put the prepared cetylpyridinium chloride, xanthan gum, mannitol and magnesium stearate into the three-dimensional mixer, and mix for 45 minutes.

[0032] 4) tableting and packaging.

Embodiment 2

[0034]

[0035] Preparation Process:

[0036] 1) Pretreatment of raw and auxiliary materials: Cetylpyridinium chloride, xanthan gum, and mannitol are passed through a 80-mesh sieve, and magnesium stearate is passed through a 100-mesh sieve.

[0037] 2) Weighing: Take cetylpyridinium chloride, xanthan gum, mannitol and magnesium stearate according to the prescription.

[0038] 3) Total blending: put the prepared cetylpyridinium chloride, xanthan gum, mannitol and magnesium stearate into the three-dimensional mixer, and mix for 45 minutes.

[0039] 4) tableting and packaging.

Embodiment 3

[0041]

[0042] Preparation Process:

[0043] 1) Pretreatment of raw and auxiliary materials: Cetylpyridinium chloride, xanthan gum, and mannitol are passed through a 80-mesh sieve, and magnesium stearate is passed through a 100-mesh sieve.

[0044] 2) Weighing: Take cetylpyridinium chloride, xanthan gum, mannitol and magnesium stearate according to the prescription.

[0045] 3) Total blending: put the prepared cetylpyridinium chloride, xanthan gum, mannitol and magnesium stearate into the three-dimensional mixer, and mix for 45 minutes.

[0046] 4) tableting and packaging.

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PUM

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Abstract

The invention provides a cetylpyridinium chloride-containing buccal tablet and a preparation technology thereof. The buccal tablet is prepared from cetylpyridinium chloride, xanthan gum, mannitol andmagnesium stearate. The buccal tablet has the advantages of simple prescription composition, great reduction of side effects possibly caused by auxiliary materials, safe and nontoxic auxiliary materials, obvious prolongation of the lasting time of the medicine effect, simple product process, convenience in large-scale production, and safe and reliable product quality. The buccal tablet solves theproblems of medication convenience and compliance of patients.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a buccal tablet containing cetylpyridinium chloride and a preparation process thereof. Background technique [0002] As a cationic surfactant, cetylpyridinium chloride has been highly appraised all over the world for its excellent bactericidal activity and safety. At present, it is widely used in the adjuvant treatment of oral infectious diseases, which can reduce or inhibit the formation of dental plaque, keep the mouth clean, and remove oral odor. drug stability. [0003] The cetylpyridinium chloride buccal tablets currently on the market are produced by Japan Iwaki Pharmaceutical Co., Ltd. Produced by China Taiwan Huang's Pharmaceutical Co., Ltd. and produced by Shandong New Times Pharmaceutical Co., Ltd. Wait. in The excipients used are carbomer, hydroxypropyl cellulose, sucrose, magnesium stearate, povidone and essence. The excipients used are carbomer, h...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/36A61K47/26A61K47/12A61K31/4425A61P1/02A61P31/04A61P11/04
CPCA61K9/2013A61K9/2018A61K9/205A61K31/4425A61P1/02A61P11/04A61P31/04
Inventor 倪菁龚太权彭涛
Owner 四川健能制药有限公司
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