Application of FBXL6 as target in preparation of antitumor drugs
An anti-tumor drug, FBXL6 technology, applied in the field of tumor drug target research, can solve problems such as ambiguity
Active Publication Date: 2020-04-14
THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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Problems solved by technology
Various F-box proteins play an important role in various biochemical reactions and signaling pathways, but how they participate in the occurrence and development of diseases is still unclear and remains to be explored
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[0032] 1. FBXL6 is associated with poor survival prognosis of cancer patients
[0033] 1.1 High expression of FBXL6 gene is associated with poor prognosis of 7 cancers
[0034] The present invention uses The Cancer Genome Atlas (TCGA) database to analyze differences in FBXL6 gene expression and adrenocortical carcinoma (ACC), pancreatic cancer (PAAD), hepatocellular carcinoma (LIHC), renal clear cell carcinoma (KIRC), chromophobe cell carcinoma (KICH), bile cancer (CHOL), colon cancer (COAD) 7 kinds of cancer patients survival prognosis. Survival analysis of 1508 patients showed that the expression level of FBXL6 gene was significantly correlated with prognosis (p Figure 1a ), suggesting that FBXL6 can be used as an indicator of potential clinical prognosis.
[0035] 1.2 High expression of FBXL6 protein is associated with poor prognosis of liver cancer
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The invention relates to an application of FBXL6 as a target in preparation of antitumor drugs. Through a series of in-vitro experiments, it is found that the FBXL6 gene plays a key role in promotingtumor cell proliferation and metastasis. Through in-vivo experiments of transgenic mice, it is found that the FBXL6 gene can promote generation of tumors of the mice, and the FBXL6 single gene plays akey role in regulation and control of the tumors of the mice. Based on the difference of FBXL6 gene expression between normal cells and tumor cells, it is found for the first time that FBXL6 can be used as a new anti-tumor drug target and has potential clinical application value in tumor immunotherapy.
Description
Technical field [0001] The invention belongs to the technical field of tumor drug target research, and relates to the application of FBXL6 as a target in preparing antitumor drugs. Background technique [0002] Malignant tumor is one of the diseases with the highest fatality rate in the world, which seriously endangers human health and life. Conventional methods such as surgical resection, radiotherapy, and chemotherapy are mostly used in tumor treatment, but these methods show their limitations for patients with advanced and metastatic malignant tumors. With the development of tumor biology and related disciplines, more and more evidences show that tumor is a progressively heterogeneous disease, a long-term process with multiple causes, multiple stages, and multiple genes. [0003] In recent years, the research and development hotspot of anti-tumor drugs has shifted from traditional cytotoxic drugs to a new generation of tumor drugs that can specifically target gene targets. For...
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IPC IPC(8): C12Q1/6886A61K45/00A61P35/00
CPCC12Q1/6886A61K45/00A61P35/00C12Q2600/158
Inventor 谢传明林晓彤张捷方蕾
Owner THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV