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A biological polysaccharide flushing solution suitable for orthopedic surgery and its preparation method

A technology of biological polysaccharides and orthopedic surgery, which is applied in the direction of surgical drugs, medical preparations containing active ingredients, drug combinations, etc., and can solve problems such as adding bioglass

Active Publication Date: 2022-04-19
江苏开源康达医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After a patent search, there is no report of adding bioglass to the flushing solution at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: a kind of biological polysaccharide flushing liquid suitable for orthopedic surgery, by weight percentage, comprises sodium carboxymethyl cellulose 3%, carboxymethyl chitosan 2%, bioglass 10%, acid-base regulator 0.05%, and the balance is ultrapure water. The particle size of the bioactive glass is <180 μm.

[0017] Disperse sodium carboxymethylcellulose in purified water and stir completely to obtain solution A. Disperse carboxymethyl chitosan in purified water, stir and dissolve thoroughly to obtain solution B. Mix solutions A and B, add bioglass and stir thoroughly to obtain solution C. Add an acid-base regulator to adjust the pH value of solution C to between 5.5-7.5. Sampling is taken to measure properties such as pH value and viscosity, and after passing the test, it is filled, sealed, packaged, and sterilized to obtain a biopolysaccharide flushing solution suitable for orthopedic surgery.

Embodiment 2

[0018] Embodiment 2: A kind of biological polysaccharide flushing liquid suitable for orthopedic surgery, by weight percentage, comprises sodium carboxymethyl cellulose 5%, carboxymethyl chitosan 5%, bioglass 15%, acid-base regulator 0.05%, and the balance is ultrapure water. The particle size of the bioactive glass is <180 μm.

[0019] Disperse sodium carboxymethylcellulose in purified water and stir completely to obtain solution A. Disperse carboxymethyl chitosan in purified water, stir and dissolve thoroughly to obtain solution B. Mix solutions A and B, add bioglass and stir thoroughly to obtain solution C. Add an acid-base regulator to adjust the pH value of solution C to between 5.5-7.5. Sampling is taken to measure properties such as pH value and viscosity, and after passing the test, it is filled, sealed, packaged, and sterilized to obtain a biopolysaccharide flushing solution suitable for orthopedic surgery.

[0020] Control group 1: by weight percentage, including...

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PUM

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Abstract

The invention discloses a biological polysaccharide flushing solution suitable for orthopedic surgery and a preparation method thereof, which comprises 0.5% to 6% of carboxymethyl cellulose sodium, 0.3 to 4% of carboxymethyl chitosan, and a preparation method thereof. 5% to 20% of biological glass, 0.01 to 0.1% of acid-base regulator, and the balance is ultrapure water. The biological polysaccharide flushing solution made of carboxymethyl cellulose sodium, carboxymethyl chitosan and bio-glass as main raw materials in the present invention, wherein carboxymethyl chitosan has anti-inflammatory and antibacterial effects, and the bio-glass is covered with the flushing liquid Increase bone repair ability on the wound surface, while sodium carboxymethylcellulose can form a physical barrier to isolate foreign bacteria. In orthopedic surgery, after washing the wound surface, it can simultaneously clean the wound, inhibit bacteria and reduce inflammation, increase bone repair, and finally form a physical barrier to provide a favorable growth environment for wound healing.

Description

technical field [0001] The invention relates to a biological polysaccharide flushing solution suitable for orthopedic surgery and a preparation method thereof. Background technique [0002] In the treatment of traumatic wounds or surgical incisions in surgical operations, most of the clinical application of physiological saline, or the use of pure carboxymethylcellulose sodium and carboxymethyl chitosan as raw materials for washing the wounds or incisions rinse. Conventional saline can only achieve a simple flushing and cleaning effect on wounds or incisions, while the flushing solution added with plant cellulose or chitosan has increased antibacterial, anti-inflammatory and anti-adhesive properties compared with normal saline. The stickiness and other effects only provide a healing environment for the wound, and the ingredients in it have little effect on promoting the rapid healing of the wound. [0003] Water-soluble sodium carboxymethyl cellulose with negatively charge...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/00A61K9/08A61P41/00A61P17/02A61P31/02A61P29/00A61P19/08A61K31/722A61K31/717
CPCA61K33/00A61K31/722A61K31/717A61K9/08A61K9/0014A61P41/00A61P17/02A61P31/02A61P29/00A61P19/08A61K2300/00
Inventor 孙开源
Owner 江苏开源康达医疗器械有限公司