Preparation method of tetrapanax papyriferus extract and pharmaceutical composition containing tetrapanax papyriferus extract

A technology of Chasegrass and extract, applied in the field of preparation method and pharmaceutical composition containing Chasecao extract, can solve the problems of drug resistance and drug residues, reduce breast diseases, extract at low temperature, and improve lactation ability Effect

Inactive Publication Date: 2020-04-17
四川辉氏生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the extensive use of antibiotics, the problems of drug resistance and drug residues are becoming more and more serious. Feed additives become a new direction to promote the healthy development of animal husbandry

Method used

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  • Preparation method of tetrapanax papyriferus extract and pharmaceutical composition containing tetrapanax papyriferus extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A preparation method of Chase grass extract, comprising the following steps:

[0024] Step 1. Pulverize Chase Grass, then mix 100g of pulverized Chase Grass particles with 2g of sodium hydroxide, then add it to a ball mill jar, and ball-mill the balls in the ball mill jar; feed liquid nitrogen into the ball mill jar to make Chase Grass Submerge the particles and sodium hydroxide in liquid nitrogen at a temperature of -170°C, and keep the volatile amount of liquid nitrogen and the amount of feed in balance to stabilize the liquid level; start ball milling after 25 minutes of constant temperature, and ball mill for 60 minutes; after ball milling, ball mill the tank Transfer to a vacuum glove box, place it for 24 hours, and collect the ball milling material; the consumption of the ball milling ball is to add 30 ball milling balls per 1g of Datong grass particles; the material of the ball milling tank and the ball milling ball is agate; the speed of the ball milling It is 5...

Embodiment 2

[0029] A preparation method of Chase grass extract, comprising the following steps:

[0030] Step 1: Pulverize Chase Grass, then mix 100g of pulverized Chase Grass particles with 1g of sodium hydroxide, then add it to a ball mill jar, and ball-mill the balls in the ball mill jar; feed liquid nitrogen into the ball mill jar to make Chase Grass Submerge the granules and sodium hydroxide in liquid nitrogen at a temperature of -165°C, and maintain a balance between the volatile amount of liquid nitrogen and the input amount to stabilize the liquid level; start ball milling after 20 minutes of constant temperature, and ball mill for 45 minutes; after ball milling, ball mill jar Transfer to a vacuum glove box, place it for 12 hours, and collect the ball milling material; the consumption of the ball milling ball is to add 40 ball milling balls per 1g of Datong grass particles; the material of the ball milling tank and ball milling ball is agate; the speed of the ball milling 400r / min...

Embodiment 3

[0035] A preparation method of Chase grass extract, comprising the following steps:

[0036] Step 1. Pulverize Chase Grass, then mix 100g of pulverized Chase Grass particles with 3g of sodium hydroxide, then add it to a ball mill jar, and ball-mill the balls in the ball mill jar; feed liquid nitrogen into the ball mill jar to make Chase Grass Submerge the particles and sodium hydroxide in liquid nitrogen at a temperature of -180°C, and keep the volatilization of liquid nitrogen and the amount of feed in balance to stabilize the liquid level; start ball milling after 20 minutes of constant temperature, and ball mill for 40 minutes; after ball milling, ball mill jar Transfer to a vacuum glove box, place it for 12 hours, and collect the ball milling material; the consumption of the ball milling ball is to add 50 ball milling balls per 1g of Datong grass particles; the material of the ball milling tank and the ball milling ball is agate; the speed of the ball milling 450r / min;

...

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Abstract

The invention discloses a preparation method of a tetrapanax papyriferus extract and a pharmaceutical composition containing the tetrapanax papyriferus extract. The preparation method comprises the following steps: pulverizing tetrapanax papyriferus, carrying out low-temperature ball milling, and collecting a ball-milled material; adding the ball-milled material into ethanol, carrying out ball-milling extraction, and carrying out ultrasonic extraction on filter residues; obtaining a supernatant; performing high static pressure treatment on the supernatant; and carrying out flash evaporation concentration on the mixed supernatant subjected to high static pressure treatment, and carrying out spray drying to obtain the tetrapanax papyriferus extract. According to the method, ball-milling extraction is combined with ultrasonic extraction, the extraction temperature is low, and effective components of tetrapanax papyriferus cannot be damaged; the obtained tetrapanax papyriferus extract is combined with other medicinal components for use, so that the lactation capacity of sows can be effectively improved, and breast diseases of the sows are reduced.

Description

technical field [0001] The present invention relates to a method for preparing an extract of Chasegrass and a pharmaceutical composition containing the extract of Chasegrass, in particular to a pharmaceutical composition prepared by using the extract of Chasegrass for sows. Background technique [0002] Sow feeding is one of the important links in pig production, and the healthy lactation of sows is very important to the feeding of sows. The key problems that plague the production of breeding pigs are the frequent occurrence of mammary diseases and low lactation ability of sows, which lead to nutritional deficiencies, high diarrhea rate, slow growth, low survival rate of piglets, low weaning litter weight and small individual body weight, so the sows should be improved Udder health and lactation ability can promote the growth and development of suckling piglets and increase the reproductive efficiency of sows, which can further reduce costs and improve economic benefits. Ho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/25A61K38/02A23K10/26A23K10/30A23K20/147A23K50/30A61P15/14A61K35/612
CPCA61K36/25A61K36/195A61K36/315A61K36/533A61K36/185A61K38/02A61K35/612A23K50/30A23K10/30A23K20/147A23K10/26A61P15/14A61K2236/15A61K2236/333A61K2300/00
Inventor 胡进成
Owner 四川辉氏生物技术有限公司
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