Method and device for forming drug coating layer

A drug coating, drug technology, applied in the direction of drug devices, coatings, balloon catheters, etc., to achieve the effect of efficient removal

Active Publication Date: 2020-04-17
TERUMO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, if the lesion is forcibly expanded, smooth muscle cells m...

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  • Method and device for forming drug coating layer
  • Method and device for forming drug coating layer
  • Method and device for forming drug coating layer

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Embodiment Construction

[0039] Hereinafter, embodiments of the present invention will be described with reference to the drawings. It should be noted that the dimensional ratios in the drawings may be exaggerated and may differ from actual ratios as required for description.

[0040] The method for forming the drug coating according to the embodiment of the present invention is as follows: Figure 1~3 As shown, a drug coating 40 is formed on the surface of the balloon 30 of the drug-eluting balloon catheter 10 . In this specification, the side where the balloon catheter 10 is inserted into the lumen of the living body is referred to as the "distal side", and the side where the operation is performed is referred to as the "proximal side".

[0041] First, the structure of the balloon catheter 10 will be described. The balloon catheter 10 has a long catheter body 20 , a balloon 30 disposed on the distal portion of the catheter body 20 , a drug coating 40 disposed on the surface of the balloon 30 , and...

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Abstract

Provided are a method and device for forming a drug coating layer with which it is possible to suppress damage to elongated drug crystals on the surface of a balloon and to maintain a suitable shape for causing the drug crystals to act on a living body. A method for forming a drug coating layer (40) in which a plurality of elongated bodies (42), which are crystals of a water-insoluble drug havinga length axis, are formed on the surface of a balloon (30), wherein the method has: a step in which a coating solution that includes a water-insoluble drug, a water-soluble additive, an organic solvent, and water is supplied to the surface of the balloon (30), the organic solvent and the water are caused to evaporate, and each of an additive layer (41) which includes the water-soluble additive andprojecting crystals (48) the tips of which project from the additive layer (41) are formed; a step in which a surplus portion (49) of the projecting crystals (48) that projects from the additive layer (41) is cut out from a site surrounded by the additive layer (41), and the site surrounded by the additive layer (41) is formed into an elongated body (42); and a step in which the cut-out surplus portion (49) is removed from the drug coating layer (40).

Description

technical field [0001] The present invention relates to a method and a device for forming a drug coating on the surface of a balloon. Background technique [0002] In recent years, balloon catheters have been used to improve lesion (stenosis) in the lumen of a living body. A balloon catheter generally has an elongated shaft and a radially expandable balloon disposed on the distal side of the shaft. The lesion can be expanded by expanding the deflated balloon after reaching the target position in the body through the thin living body lumen. [0003] However, if the lesion is forcibly expanded, smooth muscle cells may proliferate excessively and new stenosis (restenosis) may occur in the lesion. Therefore, recently, a drug eluting balloon (Drug Eluting Balloon: DEB) in which a drug for inhibiting stenosis is coated on the surface of the balloon is used. The drug-eluting balloon instantly releases the drug coated on the surface to the lesion by dilation, thereby suppressing ...

Claims

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Application Information

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IPC IPC(8): A61L29/16A61L29/08A61L29/12A61M25/00A61M25/10
CPCA61L29/08A61L29/16A61M25/00A61M25/10A61L2300/416A61L2300/63A61L2300/606A61L2420/02A61L2300/204A61L2300/216A61M25/1029A61M2025/1031A61M2025/105A61M2207/10
Inventor 黑崎靖夫后藤博北川悠乃
Owner TERUMO KK
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