A long-acting antibacterial and antifungal agent, its preparation method and application in space station environment

An antibacterial and antifungal agent, space station technology, applied in the field of antibacterial and antifungal agents, can solve the problems of inability to achieve long-term, effective control of microbial reproduction, limited silver ion antibacterial time, hidden dangers to astronauts' health, etc., to achieve drug resistance and no discoloration No hidden dangers, no effects of toxic ingredients

Active Publication Date: 2021-08-24
SHENZHOUSPACEBIOTECHGRP
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, silver ions have a limited antibacterial time and are easy to change color after being used on textiles. They are not universal in the antibacterial application of various materials in the space station.
And more importantly, the accumulation toxicity of silver nano-ions in the human body has received more and more attention. Therefore, the large-scale use of silver-ion antibacterial products in the space station may cause hidden dangers to the health of astronauts.
[0004] To sum up, the excessive reproduction of microorganisms in space is a safety hazard that threatens the health of astronauts and the normal operation of components in the cabin. The existing methods cannot achieve the purpose of long-term and effective control of microbial reproduction.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A long-acting antibacterial and antifungal agent, its preparation method and application in space station environment
  • A long-acting antibacterial and antifungal agent, its preparation method and application in space station environment
  • A long-acting antibacterial and antifungal agent, its preparation method and application in space station environment

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] The present invention provides the preparation method of the long-acting antibacterial antifungal agent described in the above scheme, comprising the following steps:

[0028] Mix organic silicon quaternary ammonium salt, stabilizer, synergist, film-forming agent and water to obtain long-acting antibacterial and antifungal agent.

[0029] In a specific embodiment of the present invention, it is preferable to use commercially available organic silicon quaternary ammonium salt solution as raw material to prepare the antibacterial and antifungal agent of the present invention. When using commercially available organic silicon quaternary ammonium salt solution as raw material, it is preferred to use propylene glycol as The organic silicon quaternary ammonium salt solution of solvent, the mass concentration of described organic silicon quaternary ammonium salt solution is preferably 10~60%, more preferably 50%, when using commercially available organic silicon quaternary ammo...

Embodiment 1

[0035] With organosilicon quaternary ammonium salt solution (solvent is propylene glycol, solute is (trimethoxysilyl) propyl group-N-octadecyl dimethyl ammonium chloride, mass concentration is 50%) as raw material preparation embodiment 1 Antibacterial and antifungal agent, mix organosilicon quaternary ammonium salt solution, chitosan, dopamine hydrochloride, poloxamer and water, stir for 10 minutes, use 0.1% sodium hydroxide solution to adjust the pH value to 8.5, and fill.

[0036] In the obtained product, every 100 g product contains: 0.5 g of organosilicon quaternary ammonium salt, 0.5 g of propylene glycol, 1.0 g of chitosan, 0.2 g of dopamine hydrochloride, 4071.2 g of poloxamer, and the balance of water.

[0037] Stability test: The test temperature is 25°C, and the drug stability test box is placed. The results show that the product can be stored stably at room temperature for more than 2 years.

[0038] Anti-mildew test on the surface of textiles, using Aspergillus ni...

Embodiment 2

[0046] Example 2 was prepared from organosilicon quaternary ammonium salt solution (the solvent is propylene glycol, the solute is (triethoxysilyl) propyl-N-octadecyldimethylammonium chloride, and the mass concentration is 60%) For antibacterial and antifungal agents, mix organosilicon quaternary ammonium salt solution, pentylene glycol, chitosan, dopamine hydrochloride, polyvinylpyrrolidone K30 and water, stir for 10 minutes, and fill.

[0047] In the obtained product, every 100 g of the product contains: 0.2 g of organosilicon quaternary ammonium salt, 0.13 g of propylene glycol, 0.8 g of pentylene glycol, 1.0 g of chitosan, 0.1 g of dopamine hydrochloride, 0.5 g of polyvinylpyrrolidone K, and the balance of water.

[0048] The stability test was carried out according to the method of Example 1, and the results showed that the product could be stored stably at room temperature for more than 1 year.

[0049] Anti-mildew test on aluminum alloy surface, using Aspergillus niger,...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the technical field of antibacterial and antifungal agents, and provides a long-acting antibacterial and antifungal agent, a preparation method thereof and an application in a space station environment. The long-acting antibacterial and antifungal agent provided by the present invention uses organosilicon quaternary ammonium salt as the main bactericidal component, which can inhibit bacteria, yeast and fungi for a long time, has high safety, and has no hidden dangers of acute toxicity and cumulative toxicity; the antibacterial and antifungal agent of the present invention The mold agent has long-acting antibacterial and antifungal properties, and bacterial molds are not easy to produce drug resistance; there is no hidden danger of discoloration, no toxic components, and can be stored for a long time; further, the present invention uses propylene glycol, etc. as a stabilizer, which can reduce the release of voc and avoid methanol The volatilization of toxic gases and other toxic gases in the special environment of the space station affects the health of astronauts. The long-acting antibacterial and antifungal agent provided by the invention can meet the long-acting antibacterial and antifungal requirements of aluminum alloys and textiles in the cabin of the space station. At the same time, the product has a low voc release amount and meets the air quality requirements of the space station.

Description

technical field [0001] The invention relates to the technical field of antibacterial and antifungal agents, in particular to a long-acting antibacterial and antifungal agent, a preparation method thereof and an application in a space station environment. Background technique [0002] Microorganisms on the space station will affect the health of astronauts and the safety of the cabin environment. Studies have shown that the growth rate of microorganisms on the space station is significantly faster than that of the ground control group. Researchers found 84 kinds of microorganisms in the cabin of the International Space Station, and identified 18 types of bacteria and 12 types of fungi, including 49 types of bacteria and 35 types of fungi. Microorganisms exist in the air, water and surfaces of the Mir space station. In the International Space Station, the fungi attached to the surface of materials are mainly Penicillium, Aspergillus and Cladosporium, all of which have a tend...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A01N55/10A01N33/10A01N37/44A01N43/16A01P1/00A01P3/00
CPCA01N33/10A01N37/44A01N43/16A01N55/00
Inventor 王小雪李飞李明刘庆华郭飞马王凯马峰
Owner SHENZHOUSPACEBIOTECHGRP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap