A long-acting antibacterial and antifungal agent, its preparation method and application in space station environment
An antibacterial and antifungal agent, space station technology, applied in the field of antibacterial and antifungal agents, can solve the problems of inability to achieve long-term, effective control of microbial reproduction, limited silver ion antibacterial time, hidden dangers to astronauts' health, etc., to achieve drug resistance and no discoloration No hidden dangers, no effects of toxic ingredients
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[0027] The present invention provides the preparation method of the long-acting antibacterial antifungal agent described in the above scheme, comprising the following steps:
[0028] Mix organic silicon quaternary ammonium salt, stabilizer, synergist, film-forming agent and water to obtain long-acting antibacterial and antifungal agent.
[0029] In a specific embodiment of the present invention, it is preferable to use commercially available organic silicon quaternary ammonium salt solution as raw material to prepare the antibacterial and antifungal agent of the present invention. When using commercially available organic silicon quaternary ammonium salt solution as raw material, it is preferred to use propylene glycol as The organic silicon quaternary ammonium salt solution of solvent, the mass concentration of described organic silicon quaternary ammonium salt solution is preferably 10~60%, more preferably 50%, when using commercially available organic silicon quaternary ammo...
Embodiment 1
[0035] With organosilicon quaternary ammonium salt solution (solvent is propylene glycol, solute is (trimethoxysilyl) propyl group-N-octadecyl dimethyl ammonium chloride, mass concentration is 50%) as raw material preparation embodiment 1 Antibacterial and antifungal agent, mix organosilicon quaternary ammonium salt solution, chitosan, dopamine hydrochloride, poloxamer and water, stir for 10 minutes, use 0.1% sodium hydroxide solution to adjust the pH value to 8.5, and fill.
[0036] In the obtained product, every 100 g product contains: 0.5 g of organosilicon quaternary ammonium salt, 0.5 g of propylene glycol, 1.0 g of chitosan, 0.2 g of dopamine hydrochloride, 4071.2 g of poloxamer, and the balance of water.
[0037] Stability test: The test temperature is 25°C, and the drug stability test box is placed. The results show that the product can be stored stably at room temperature for more than 2 years.
[0038] Anti-mildew test on the surface of textiles, using Aspergillus ni...
Embodiment 2
[0046] Example 2 was prepared from organosilicon quaternary ammonium salt solution (the solvent is propylene glycol, the solute is (triethoxysilyl) propyl-N-octadecyldimethylammonium chloride, and the mass concentration is 60%) For antibacterial and antifungal agents, mix organosilicon quaternary ammonium salt solution, pentylene glycol, chitosan, dopamine hydrochloride, polyvinylpyrrolidone K30 and water, stir for 10 minutes, and fill.
[0047] In the obtained product, every 100 g of the product contains: 0.2 g of organosilicon quaternary ammonium salt, 0.13 g of propylene glycol, 0.8 g of pentylene glycol, 1.0 g of chitosan, 0.1 g of dopamine hydrochloride, 0.5 g of polyvinylpyrrolidone K, and the balance of water.
[0048] The stability test was carried out according to the method of Example 1, and the results showed that the product could be stored stably at room temperature for more than 1 year.
[0049] Anti-mildew test on aluminum alloy surface, using Aspergillus niger,...
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