Injectable colored gel pad for gastrointestinal mucosa delamination and application thereof.

Abstract

The invention relates to the field of biomedical engineering, and discloses an injectable colored gel pad for gastrointestinal mucosa delamination and application thereof. A fibroin solution, a chitosan solution or a gelatin solution is firstly injected into the submucosa of the digestive tract; and then, a genipin solution containing disodium glycerophosphate is injected into the submucosa of thedigestive tract; and a gel pad is formed in the submucosa of the digestive tract after a cross-linking reaction occurs, and is used for separating a pathological mucosal layer from a muscle layer tofacilitate the dissection of the pathological mucosal layer. The forming time of the gel pad is controlled by controlling the dosage of the genipin and the disodium glycerophosphate in the genipin solution. The injectable colored gel pad for gastrointestinal mucosa delamination has the advantages that used materials are all liquid materials with low cytotoxicity and high biocompatibility; the formed gel pad is dark blue, so that pathological tissues can be clearly marked, and the submucosal dissection operation is more convenient and safer; a good clinical use effect is achieved; and the injectable colored gel pad is worthy of clinical popularization.

Description

Technical field [0001] The invention relates to the field of biomedical engineering, and relates to an injectable colored gel pad used for the stratification of the digestive tract mucosa and its application. Background technique [0002] Early gastrointestinal cancer refers to cancer of the gastrointestinal tract located in the mucosa or submucosa, regardless of the size of the lesion and whether there is lymph node metastasis. Endoscopic mucosal resection (EMR) can perform endoscopic resection of early gastrointestinal cancer. The resection scope includes the mucosal layer, part of the submucosa and part of the normal mucosa around the cancer tissue. Endoscopic submucosal dissection (ESD) is developed on the basis of EMR technology. The current clinical treatment results show that ESD can improve the one-time complete resection rate and histologically curative resection rate. It is a kind of treatment for early gastrointestinal cancer. A safe and effective method has become on...

AI Technical Summary

Problems solved by technology

Although methylene blue can be used as a chemical indicator, dye, biological stain and medicine, it is often used clinically to treat urinary calculi, obliterative vasculitis, and neurodermatitis, but the International Agency for Research on Cancer of the World Health Organization lists methylene blue in 3 In the list of carcinoids, it is unscientific to use it clinically as a biological chromogenic agent