The invention belongs to the field of medicinal chemistry, and particularly relates to phosphoglyceromutase 1. The invention provides an inhibitor of the phosphoglyceromutase 1; a specific structure is as shown in the formula I as shown in the description. The invention further provides a synthesis method of the structure as shown in the formula I as shown in the description and application in diseases related to cell apoptosis and tumors thereof; the diseases include various kinds of cancer of stomach cancer, liver cancer, myelomas, bladder cancer, prostatic cancer, breast cancer, rectal cancer, head and neck cancer, lung cancer, melanomas, ovarian cancer, cervical cancer, esophagus cancer and the like.