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Composition for enhancing water solubility of curcumin and preparation method of composition

A technology of curcumin and composition, which is applied to the composition and preparation field for enhancing the water-solubility of curcumin, can solve the problems such as low bioavailability and limit application, and achieves the advantages of avoiding oxidation possibility, improving absorption status and increasing water-solubility. Effect

Active Publication Date: 2019-03-19
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But its low bioavailability limits its application in health care and medicine

Method used

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  • Composition for enhancing water solubility of curcumin and preparation method of composition
  • Composition for enhancing water solubility of curcumin and preparation method of composition

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Embodiment 1

[0028] A composition for enhancing the water solubility of curcumin, comprising the following components: 0.9 kg of curcumin, 14.0 kg of soybean lecithin, and 1.8 kg of resistant dextrin.

[0029] The preparation method of the composition that present embodiment strengthens curcumin water solubility is as follows:

[0030] (1) Take curcumin 0.9kg, soybean lecithin 14.0kg, resistant dextrin 1.8kg, 95% ethanol 275.0L;

[0031] (2) 14.0 kg of soybean phospholipids and 140.0 L of 95% ethanol were placed in an extraction stirring tank, extracted for 4 hours, and filtered through a 5 μm filter to obtain a phospholipid ethanol extract;

[0032] (3) 0.9kg of curcumin, phospholipid ethanol extract, and 135.0L of 95% ethanol are placed in an extraction and stirring tank, and associated for 8h to obtain curcumin association liquid;

[0033] (4) the curcumin association liquid is placed in a double-effect concentrator and concentrated to obtain the curcumin association concentrate;

[0...

Embodiment 2

[0036] A composition for enhancing the water solubility of curcumin, comprising the following components: 3.5kg of curcumin, 1.2kg of soybean lecithin, and 7.0kg of resistant dextrin.

[0037] The preparation method of the composition that present embodiment strengthens curcumin water solubility is as follows:

[0038] (1) Take curcumin 3.5kg, soybean lecithin 1.2kg, resistant dextrin 7.0kg, 95% ethanol 718.0L;

[0039] (2) 1.2 kg of soybean phospholipids and 18.0 L of 95% ethanol were placed in an extraction stirring tank, extracted for 4 hours, and filtered through a 5 μm filter to obtain a phospholipid ethanol extract;

[0040] (3) 3.5kg of curcumin, phospholipid ethanol extract, and 700.0L of 95% ethanol are placed in an extraction and stirring tank, and associated for 8h to obtain curcumin association liquid;

[0041] (4) the curcumin association liquid is placed in a double-effect concentrator and concentrated to obtain the curcumin association concentrate;

[0042] (5...

Embodiment 3

[0044] A composition for enhancing the water solubility of curcumin, comprising the following components: 1.0 kg of curcumin, 6.0 kg of soybean lecithin, and 2.0 kg of resistant dextrin.

[0045] The preparation method of the composition that present embodiment strengthens curcumin water solubility is as follows:

[0046] (1) Take curcumin 1.0kg, soybean lecithin 6.0kg, resistant dextrin 2.0kg, 95% ethanol 160.0L;

[0047](2) 6.0 kg of soybean phospholipids and 120.0 L of 95% ethanol were placed in an extraction stirring tank, extracted for 4 hours, and filtered through a 5 μm filter to obtain a phospholipid ethanol extract;

[0048] (3) 1.0kg of curcumin, phospholipid ethanol extract, and 40.0L of 95% ethanol were placed in an extraction and stirring tank, and associated for 8h to obtain curcumin association liquid;

[0049] (4) the curcumin association liquid is placed in a double-effect concentrator and concentrated to obtain the curcumin association concentrate;

[0050]...

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Abstract

The invention relates to a composition for enhancing the water solubility of curcumin and a preparation method of the composition and belongs to the technical field of foods and health-care products.The composition provided by the invention comprises the following components in parts by weight: 0.1 to 35.0 parts of the curcumin or a derivative thereof, 0.03 to 560.0 parts of phospholipid containing glycerol phosphate or the glycerol phosphate and 0.2 to 70.0 part of resistant dextrin. In the composition provided by the invention, the dissolution rate and the releasing rate of the composition,and the in-vivo transportation efficiency and the bioavailability of the curcumin are cooperatively enhanced through the glycerol phosphate and the resistant dextrin, and the intestinal absorption condition of the lipid-soluble curcumin is improved; and the types and forms, and a functional application range of a curcumin solid preparation are expanded under the condition that original propertiesand anti-oxidization performance of the curcumin are not influenced.

Description

technical field [0001] The invention relates to a composition for enhancing the water solubility of curcumin and a preparation method thereof, belonging to the technical field of food and health products. Background technique [0002] Curcumin is a polyphenolic compound with strong coloring ability. It is one of the seven largest natural food colorings sold in the world. It is a natural food additive recognized by the World Health Organization and the US Food and Drug Administration. Curcumin molecule contains multiple double bonds, as well as active groups such as phenolic hydroxyl group and carbonyl group, which are used in anti-tumor, anti-oxidation, free radical scavenging, anti-microbial and on cardiovascular system, digestive system, osteoarthritis caused by inflammation , cancer, rheumatoid arthritis, ulcerative enteritis, cardiovascular diseases and other aspects are effective. But its low bioavailability limits its application in health care and medicine. When stu...

Claims

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Application Information

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IPC IPC(8): A61K47/24A61K47/36A61K31/12A61P35/00A61P39/06A61P31/00A61P9/00A61P1/00A61P29/00A61P19/02A61P1/04A23L33/105A23L29/10A23L29/30
CPCA23V2002/00A61K31/12A61K47/24A61K47/36A23L29/10A23L29/35A23L33/105A61P1/00A61P1/04A61P9/00A61P19/02A61P29/00A61P31/00A61P35/00A61P39/06A23V2200/222A23V2200/30A23V2200/14A23V2250/2112A23V2250/5114A23V2250/082
Inventor 刘洁瑜牛亚伟李菁关伟健袁诚唐顺之许文东蒙庚海
Owner GUANGZHOU HANFANG PHARMA
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