Novel multivalent carrier vaccine for shrimp and application thereof

A carrier vaccine and prawn technology, applied in the field of genetic bioengineering, can solve the problems of unsatisfactory, inconvenient administration, and difficulty in the protection period of vaccine immunity beyond 28 days, etc., and achieve the effect of long protection period and long multivalent cross protection
CN102895677AActive Publication Date: 2013-01-30马悦 +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
马悦
Publication Date
2013-01-30

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Abstract

The invention relates to a novel multivalent carrier vaccine for a shrimp. The vaccine is characterized by comprising a bacillus subtilis recombination strain obtained by a genetic engineering technique, the strain belongs to the category of bacillus subtilis HT5303 and is preserved in China Center for Type Culture Collection, and the preservation number is CCTCC NO.: M 2012395. When spores are formed by the bacillus subtilis vaccine strain, white spot syndrome virus VP281 protein can be demonstrated on the surfaces of the spores, and fusion protein of cell-penetrating peptides, white spot syndrome virus VP19 and vibrio harveyi 3-glyceraldehyde-phosphate dehydrogenase (GAPDH) can be secreted and expressed when vegetative cells are formed. Compared with other vaccines, the multivalent carrier vaccine has the advantages of cross protection and long protection period. Moreover, the vaccine can be added into feeds and has the advantages of resistance against high-temperature setting of feeds and broad prospects for commercial development.
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Description

technical field

[0001] The invention belongs to the technical field of genetic bioengineering, and relates to a novel polyvalent vector vaccine for prawn white spot syndrome virus (WSSV) and vibriosis and its application, in particular to a polyvalent vaccine for preventing and treating prawn white spot syndrome and vibriosis. Valence carrier vaccines and their applications. Background technique

[0002] Shrimp is a high-value aquatic product mainly produced in Asia and Latin America for export purposes. At present, the main cultured species in my country are Penaeus vannamei, Penaeus monodon and Penaeus sinensis. However, in the past 10 years, there have been quite serious problems in shrimp farming, among which white spot syndrome virus (White spot syndrome virus, WSSV), taura virus (Taura Syndrome Virus, TSV) and Vibrio are the main culprits of the disease . Shrimp white spot syndrome (WSS) is an fulminant infectious disease caused by shrimp white spot syndrome virus (W...

Claims

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