Antibacterial product and preparation method and application thereof

Abstract

The invention discloses an antibacterial product and a preparation method and application thereof. The antibacterial product contains a quinolone drug or a pharmaceutically acceptable salt thereof, and tannin or a pharmaceutically acceptable salt thereof. The invention also discloses the preparation method and application of the antibacterial product, and a pharmaceutical preparation containing the product. The antibacterial product uses a combination of the quinolone drug and tannin, pharmacodynamics tests show that the combination product has obvious synergistic effects on sensitive bacteria, can significantly reduce the minimum bacteriostatic concentration of the quinolone drug, and reduces a use amount of the quinolone drug; and at the same time, the combination product completely eliminates the strong bitter taste of the quinolone drug and becomes completely odorless, solves the problem of poor oral compliance due to the bitter taste of the drug itself when the existing quinolonedrug is administrated, helps patients with poor tolerance, such as taking of the elderly and children is easier, and has very good application prospects.

Description

technical field [0001] The invention belongs to the technical field of medicines. More specifically, it relates to an antibacterial product and its preparation method and application. Background technique [0002] Quinolone (Quinolone) is the skeleton structure of a variety of active drug molecules. Since Lesher et al. found the first quinolone derivatives in the impurities produced in the production of the antimalarial drug chloroquine in 1962, more than 10,000 quinolone derivatives have been discovered so far. According to reports, quinolone derivatives are a hot spot in drug development. [0003] [0004] Quinolones (Quinolones) drugs refer to synthetic antibacterial drugs containing quinolone cores, which are quiescent fungicides with broad antibacterial spectrum, strong antibacterial power, high tissue concentration, good oral absorption, and no cross-resistance with other commonly used antibacterial drugs It has become an important drug for the clinical treatment ...

AI Technical Summary

Problems solved by technology

At present, this problem has not been effectively solved, and has seriously affected people's health and life safety. How to reduce the minimum inhibitory concentration of antibiotics and reduce the amount of antibiotics used is a long-term problem in this field.

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