Compound CYD19 or pharmaceutically acceptable salt thereof as Snail inhibitor, and preparation method, pharmaceutical composition and application of compound CYD19 or pharmaceutically acceptable salt thereof

A technology of inhibitors and compounds, applied in drug combinations, active ingredients of heterocyclic compounds, organic chemistry, etc., can solve the problems of uncertain mechanism research, limited compound development, no obvious inhibitory effect, etc., to reduce the level of acetylation , accelerated degradation, significant anti-tumor effect
CN111187268AActive Publication Date: 2020-05-22CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2020-05-22

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Abstract

The invention discloses a compound CYD19 which has a structure as shown a formula (I) which is described in the specification and is used as a Snail inhibitor or a pharmaceutically acceptable salt thereof, and a preparation method, a pharmaceutical composition and application of the compound CYD19 or the pharmaceutically acceptable salt thereof. The invention also discloses application of the compound in preparation of drugs for preventing or treating diseases with abnormal Snail expression. The invention especially relates to an application of the compound in preparation of antitumor and cardiovascular drugs. Pharmacological results show that the compound is highly compatible with Snail protein, and has good in-vitro anti-tumor cell proliferation effect, cell apoptosis promotion effect and tumor metastasis inhibition effect. The compound shows obvious in-vivo anti-tumor proliferation and metastasis activity in HCT-116 subcutaneous xenograft tumor nude mice and in-vivo liver metastasismodels of spleen injection, and is a potential drug clinically applicable to treatment of tumors.
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Description

technical field

[0001] The present invention relates to a Snail inhibitor or its pharmaceutically acceptable preparation method, pharmaceutical composition and use thereof, in particular to a compound CYD19 as a Snail inhibitor or a pharmaceutically acceptable salt thereof and its preparation method, pharmaceutical composition and use . Background technique

[0002] Malignant tumor is a major disease that seriously threatens human life and health. It has the characteristics of fast growth, strong invasion and infiltration ability, and often distant metastasis. The biological characteristics of tumor cells, such as abnormal proliferation, apoptosis resistance, invasion and metastasis, pose serious challenges to tumor treatment. Among them, tumor metastasis is one of the key factors that make tumors difficult to treat, and its most obvious feature is the occurrence of epithelial-mesenchymal transition (EMT). For tumor cells, EMT not only endows tumor cells with the ability t...

Claims

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