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Granular arabinose as well as preparation method and application thereof

An arabinose and granular technology, applied in the field of granular arabinose and its preparation, can solve the problems of difficulty in mixing uniformly, affecting the application effect of products, and being unable to be used as excipients and fillers for tablet products.

Inactive Publication Date: 2020-05-29
ZHEJIANG HUAKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Needle-shaped crystalline L-arabinose has almost no fluidity and single particle size, so that it is difficult to mix evenly when it is compounded with sucrose and other auxiliary materials and cannot be used in related fields, and the shape of L-arabinose has no compressibility. Cannot be used as excipients and fillers in tablet products
However, although the granular L-arabinose granulated by various binders has good fluidity and controllable particle size, for some application products with special requirements, the binder in the arabinose raw material The ingredients do not meet its formulation requirements or will affect the application effect of the product and cannot be used

Method used

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  • Granular arabinose as well as preparation method and application thereof
  • Granular arabinose as well as preparation method and application thereof
  • Granular arabinose as well as preparation method and application thereof

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preparation example Construction

[0019] The present invention also discloses a method for preparing the granular arabinose as described above, comprising the following steps:

[0020] 1) Dissolving crystalline arabinose to obtain a 50% to 60% arabinose aqueous solution, and transporting it to a constant temperature bath, controlling the temperature at 40°C to 70°C, and using it as a binder.

[0021] 2) Using a crusher to crush another group of crystalline arabinose into powder to obtain arabinose powder.

[0022] 3) Add the obtained arabinose powder into the granulator, turn on the air intake of the granulator, and pass dehumidified air into the granulation chamber (temperature 25°C, relative humidity about 5%), and the fan frequency is 25HZ~30HZ , turn on the heating, heat the air to 60°C-65°C through steam, and dry the arabinose powder in a boiling fluidized state for 30min-40min.

[0023] 4) Turn on the spray, adjust the pressure of the compressed air passing through the spray gun to 0.35MPa ~ 0.45MPa, an...

Embodiment 1

[0030] The first embodiment of the preparation method of granular arabinose of the present invention comprises the following steps:

[0031] 11) Dissolving crystalline arabinose to obtain a 50% arabinose aqueous solution, and transporting it to a constant temperature tank, controlling the temperature to 40°C, and using it as a binder.

[0032] 12) Use a crusher to crush another group of crystalline arabinose into powder to obtain arabinose powder. The particle size distribution of the powder is 2.3% above 100 mesh, 18.4% from 100 mesh to 150 mesh, and 41.4% from 150 mesh to 320 mesh , 37.9% under 320 mesh.

[0033] 13) Add the obtained arabinose powder into the granulator, and turn on the air intake of the granulator, and pass dehumidified air into the granulation chamber (temperature 25°C, relative humidity about 5%), the fan frequency is 30HZ, turn on Heating, the air is heated to 65°C by steam, and the arabinose powder is dried for 40 minutes in a boiling fluidized state. ...

Embodiment 2

[0042] The second embodiment of the preparation method of granular arabinose of the present invention comprises the following steps:

[0043] 21) Dissolving the crystalline arabinose to obtain a 55% aqueous solution of arabinose, and transporting it to a constant temperature bath, controlling the temperature to 55° C., and using it as a binder.

[0044]22) Use a crusher to crush another group of crystalline arabinose into powder to obtain arabinose powder. The particle size distribution of the powder is 2.3% above 100 mesh, 18.4% from 100 mesh to 150 mesh, and 41.4% from 150 mesh to 320 mesh , 37.9% under 320 mesh.

[0045] 23) Add the obtained arabinose powder into the granulator, and turn on the air intake of the granulator, and pass dehumidified air into the granulation chamber (temperature 25°C, relative humidity about 5%), the fan frequency is 28HZ, turn on Heating, the air is heated to 63°C by steam, and the arabinose powder is dried for 35 minutes in a boiling fluidize...

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Abstract

The invention relates to granular arabinose which is arabinose granules with a moisture content of 0.1%-0.3%, fluidity of 3.0 s / 100 g-6.0 s / 100 g and a bulk density of 0.3 g / mL-0.6 g / mL. The inventionfurther discloses a preparation method and application of the granular arabinose. Existing needle-like arabinose is produced into granules under the condition that no adhesive is contained, so that the granular arabinose reaches certain fluidity, filling ability, compressibility and grain size uniformity. The application effect of a related product can be realized, for example, the product is prone to compression forming while the accurate dose of the product is guaranteed, and tablets can be prepared; and the granular arabinose can be uniformly mixed with other granular auxiliary materials to obtain granules or subpackaged in capsules to prepare capsules and the like.

Description

technical field [0001] The invention belongs to the technical field of sugar alcohols, in particular to a granular arabinose and its preparation method and application. Background technique [0002] Arabinose is also known as L(+)-albuminose, L(+)-pentose, pectin sugar, etc. The taste of L-arabinose is very close to that of sucrose, but the sweetness is only about 50% of that of sucrose . The most important physiological effect of L-arabinose is the strong selective inhibition of the enzymes related to sucrose digestion in the small intestinal disaccharide hydrolase, which inhibits the speed and efficiency of the ingested carbohydrates into glucose and fructose, which has restrictions Sucrose and glucose are converted into glycogen and absorbed by the liver, etc., and it is safe and reliable. L-arabinose is also widely used in the fields of medicine and health food, biological experiments, bioengineering, flavors and fragrances, etc. Some directly use L-arabinose and othe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/125A23L29/30A61K47/26
CPCA23L33/125A23L29/37A61K47/26A23V2002/00A23V2250/602
Inventor 罗家星毛晨建陈德水毛宝兴龚小平戴华丽
Owner ZHEJIANG HUAKANG PHARMA
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