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Application of hsp990 in the preparation of anti-rotavirus drugs

A rotavirus and drug technology, applied in the field of preparation of anti-rotavirus drugs, can solve problems such as HSP990 that has not yet been seen

Active Publication Date: 2022-02-01
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no relevant report on the anti-rotavirus aspect of HSP990 at home and abroad.

Method used

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  • Application of hsp990 in the preparation of anti-rotavirus drugs
  • Application of hsp990 in the preparation of anti-rotavirus drugs
  • Application of hsp990 in the preparation of anti-rotavirus drugs

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0032] The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0033] The experimental method that does not indicate specific condition in the preferred embodiment, generally according to conventional conditions, such as Molecular Cloning Experiment Guideline (third edition, J. Sambrook etc., translated by Huang Peitang, etc., Science Press, 2002) described conditions, or as recommended by the manufacturer.

[0034] HSP990, Geldanamycin (GA) and 17-AAG involved in the embodiment, their chemical structural formulas are respectively as Figure 1a , Figure 1b and Figure 1c shown.

[0035] 1. HSP990 significantly inhibited the establishment of rotavirus infection

[0036] Human intestinal epithelial cells Caco-2 (purchased from ATCC, HTB-37) were inoculated in 6-well cell culture plates, using DMEM high glucose medium + 10% volume ratio of peptide bovine serum at 37°C with a volume percentage of 5% C...

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PUM

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Abstract

The invention relates to the application of HSP990 in the preparation of anti-rotavirus drugs. It is confirmed by experiments that HSP990 can establish infection in cells by inhibiting rotavirus, and prevent infected cells from producing new infectious viruses, that is, inhibit rotavirus Virus infection and replication, so as to achieve the effect of anti-rotavirus, significantly reduce the adverse consequences of diarrhea and death caused by rotavirus infection. Therefore, with it as the main active ingredient, it is expected to develop highly effective and specific anti-rotavirus drugs, which can alleviate the occurrence of rotavirus diarrhea and reduce the mortality rate of severe and fatal rotavirus infection, so as to meet the needs of clinical treatment and protect people's health.

Description

technical field [0001] The invention belongs to the technical field of anti-rotavirus drugs, and relates to the application of HSP990 in the preparation of anti-rotavirus drugs. Background technique [0002] Rotavirus (RV) infection is the main cause of diarrhea in infants and young children, causing about 125 million cases of gastroenteritis in children every year, resulting in 352,000-592,000 deaths of children under the age of 5 due to rotavirus infection, mainly in developing countries. nation. [0003] Rotavirus belongs to the family Reoviridae and is a double-stranded RNA (dsRNA) virus without a cell membrane. Each of the 11 dsRNAs wraps 1 molecule of RNA-dependent RNA polymerase (VP1) and 1 molecule of guanylate and methyltransferase ( VP3) is located at the core of the virus particle and encodes 12 proteins, including 6 structural proteins (VP1-4, 6-7) and 6 non-structural proteins (NSP1-6). VP2 constitutes the inner capsid of rotavirus to enclose the viral genome;...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61P31/14
CPCA61K31/519A61P31/14
Inventor 何海洋吴玉章
Owner ARMY MEDICAL UNIV