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Glutaraldehyde disinfectant as well as preparation method and application thereof

A technology of glutaraldehyde and disinfectant, which is applied in the field of glutaraldehyde disinfectant and its preparation, can solve problems such as difficulty in ensuring high stability and high biological activity, long sterilization time, poor stability of glutaraldehyde, etc., and achieve enhanced disinfection and sterilization effect of ability

Active Publication Date: 2020-06-05
云飞生物药业(吉林)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the disinfection of medical equipment, the common glutaraldehyde disinfectant on the market is a neutral glutaraldehyde disinfectant, usually with individually packaged sodium carbonate and sodium nitrite, which are mixed before use to provide an alkaline environment and rust removal performance, but Overall, glutaraldehyde is less stable
[0007] To sum up, the glutaraldehyde disinfectants currently on the market are generally less stable, and it is difficult to ensure high stability and high biological activity at the same time, and the instruments need to be degreased, decontaminated, and sterilized before use. long time

Method used

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  • Glutaraldehyde disinfectant as well as preparation method and application thereof
  • Glutaraldehyde disinfectant as well as preparation method and application thereof
  • Glutaraldehyde disinfectant as well as preparation method and application thereof

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preparation example Construction

[0031] Such as figure 1 As shown, the preparation method of the glutaraldehyde disinfectant provided by the embodiment of the present invention includes the following steps:

[0032] S101: Prepare raw materials in parts by weight: 2% glutaraldehyde with a purity of 49 to 51%, didecyl dimethyl ammonium chloride with a purity of 95%, polyhexamethylene guanidine hydrochloride with a purity of 95%, and a purity of 99 Add 0-25% 0.02%, 99% pure sodium bicarbonate 0.7%, 99% pure sodium nitrite 0.7%, and the balance is purified deionized water;

[0033] S102: Dissolve glutaraldehyde, didecyldimethylammonium chloride, polyhexamethyleneguanidine hydrochloride, Ping Ping 0-25, sodium bicarbonate, and sodium nitrite in purified deionized water, and stir to obtain Homogeneous solution

[0034] S103: Add purified ionized water to full volume, and perform constant volume and aging;

[0035] S104: Inspect the obtained intermediate products;

[0036] S105: If qualified, use disinfectant plastic bottle...

Embodiment

[0041] Composition of 1000kg product prescription:

[0042]

[0043] Store the prepared disinfectant at 25°C and 37°C, and measure the glutaraldehyde content regularly. The content of glutaraldehyde is determined in accordance with the method described in "Technical Specifications for Disinfection" (2002 edition).

[0044] Store at 37°C for 90 days (validity period of 2 years test), test the glutaraldehyde content of the sample, the test results are shown in the following table:

[0045]

[0046] From the data in the table, it can be seen that the product of the present invention has good stability. When the accelerated test is stored at 37°C for 90 days, the decrease rate is only 0.04%, indicating that there is almost no loss of glutaraldehyde under this condition. The product of the invention has a validity period of at least 2 years, which is comparable to the validity period of the currently marketed glutaraldehyde disinfectant. The disinfectant of the invention has a significan...

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Abstract

The invention belongs to the technical field of chemical disinfectants, and discloses a glutaraldehyde disinfectant as well as a preparation method and an application thereof. The glutaraldehyde disinfectant is prepared from the following components in parts by weight: 2% of glutaraldehyde, 0.1% of didecyl dimethyl ammonium chloride, 0.2% of polyhexamethylene guanidine hydrochloride, 0.02% of peregal 0-25, 0.7% of sodium bicarbonate, 0.7% of sodium nitrite and the balance being purified deionized water. The preparation method comprises the following steps: preparing raw materials according tothe formula mentioned above; dissolving glutaraldehyde, didecyl dimethyl ammonium chloride, polyhexamethylene guanidine hydrochloride, peregal 0-25, sodium bicarbonate and sodium nitrite in purified deionized water, stirring to obtain a homogeneous solution; adding deionized water until the total volume is constant, aging; inspecting the intermediate product; if qualified, filling the intermediateproduct into a disinfectant plastic bottle, sealing the heat of the bottle, packaging; inspecting the finished product, and storing qualified products in a finished product warehouse. The stability of the glutaraldehyde disinfectant is improved, the disinfection time is shortened; and disinfection, sterilization, cleaning, decontamination, and rust prevention are synchronously completed.

Description

Technical field [0001] The invention belongs to the technical field of chemical disinfectants, and particularly relates to a glutaraldehyde disinfectant and a preparation method and application thereof. Background technique [0002] Glutaraldehyde is a new, broad-spectrum, high-efficiency, and low-toxicity disinfectant. It can kill bacterial spores, fungal spores, mycobacteria, viruses (including hepatitis A, hepatitis B, and HIV). It is known as After formaldehyde and ethylene oxide, it is the third milestone in the history of chemical sterilization. Glutaraldehyde is the preferred disinfectant recommended by the World Health Organization (WHO) for viral hepatitis. It is also a medical disinfectant recommended by the Ministry of Health of my country. It is suitable for the disinfection and sterilization of various surgical instruments, such as endoscopes, Injection supplies, catheters, scalpels, etc. [0003] In 1908, Harries and Tank first synthesized glutaraldehyde. In 1962, i...

Claims

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Application Information

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IPC IPC(8): A01N35/02A01N33/12A01N47/44A01N59/00A01N31/04A01P3/00A01P1/00
CPCA01N31/04A01N33/12A01N35/02A01N47/44A01N59/00
Inventor 白云飞
Owner 云飞生物药业(吉林)有限公司
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