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A kind of starch hemostatic sponge and its preparation method and application

A technology of hemostatic sponge and starch, which is applied in the field of starch hemostatic sponge and its preparation, which can solve the problems of unsatisfactory water absorption and complex components, and achieve the effect of facilitating skin or organ surface bonding, no cracks and ice, and convenient curling

Active Publication Date: 2022-03-15
江苏德威兰医疗器械股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In order to improve the deficiencies of the prior art, an object of the present invention is to provide a starch hemostatic sponge, which has simple components, good safety, high water absorption, and good molding performance, and can overcome the complex composition of similar materials prepared by the prior art. , safety risks, unsatisfactory water absorption and other defects, it has a wide range of uses such as body surface wound repair and internal hemostasis

Method used

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  • A kind of starch hemostatic sponge and its preparation method and application
  • A kind of starch hemostatic sponge and its preparation method and application
  • A kind of starch hemostatic sponge and its preparation method and application

Examples

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preparation example Construction

[0052] The preparation method of the present invention will be further described in detail in conjunction with specific examples below. It should be understood that the following examples are only for illustrating and explaining the present invention, and should not be construed as limiting the protection scope of the present invention. All technologies realized based on the above contents of the present invention are covered within the scope of protection intended by the present invention.

[0053] The experimental methods used in the following examples are conventional methods unless otherwise specified; the reagents and materials used in the following examples can be obtained from commercial sources unless otherwise specified.

[0054] The starches used in the following examples were purchased from commercial sources.

Embodiment 1

[0056] Put 5g of cornstarch, 150mL of water, and 1mL of glycerin into a reaction vessel, heat and stir to 100°C, and continue to stir for 3 hours to gelatinize the starch; inject the gelatinized starch into the mold, and place it in a freeze-dryer at a temperature of minus 20°C. Pre-freeze in the freezer for 4 hours; then raise the temperature of the freezer to 0°C and keep it for 4 hours; then lower the temperature of the freezer to minus 20°C for a second pre-freeze and keep it for 4 hours; Turn on the vacuum pump at minus 60°C. When the vacuum degree drops below 20Pa, raise the temperature of the freezer to minus 5°C to start the first stage of drying and keep it for 12 hours; then raise the temperature to 30°C to start the second stage of drying and keep it 5h; the hemostatic sponge finished product 1 was obtained.

Embodiment 2-36 and comparative example 1-4

[0058] The other process steps are the same as in Example 1, except that the ratio of raw materials and process parameters are different. The selection, consumption and key process parameters of each material in the reaction are shown in Table 1 below.

[0059] Table 1

[0060]

[0061]

[0062] The hemostatic sponge 1-36 obtained in the present application has a smooth and fine surface, no cracks and ice flakes, and is soft and easy to curl. And the surface of the sponge prepared by Comparative Documents 1-4 is uneven, has cracks and ice flakes, and is not soft. For example, digital photos of hemostatic sponges 4 and 9 and scanning electron micrographs of sections, and digital photos of hemostatic sponges of comparative examples 1-3 can be found in Figure 1-Figure 3 .

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Abstract

The invention provides a starch hemostatic sponge and its preparation method and application. The hemostatic sponge is composed of starch and glycerin. The preparation method comprises: 1) heating and stirring the starch, water and glycerin to gelatinize the starch; The gelatinized starch in step 1) is poured into the mold, and placed in the freezer for initial freezing; 3) The temperature of the freezer in step 2) is adjusted to minus 10°C-5°C; 4) Step 3) The temperature of the freezer is lowered, and secondary freezing is performed to obtain a semi-finished product; 5) the semi-finished product frozen in step 4) is dried under vacuum conditions to obtain a starch hemostatic sponge. The hemostatic sponge has simple components, good safety, high water absorption rate, and good molding performance, and can overcome the defects of similar materials prepared in the prior art, such as complex components, safety risks, and unsatisfactory water absorption rate, and has the functions of body surface wound repair and internal hemostasis and other wide-ranging uses.

Description

technical field [0001] The invention relates to the technical field of a hemostatic sponge and a preparation method thereof, in particular to a starch hemostatic sponge which can be degraded and absorbed in vivo and can be directly used on bloody wounds, as well as its preparation method and application. Background technique [0002] In emergencies such as natural disasters, traffic accidents, battlefields and surgical operations, uncontrollable massive bleeding will directly endanger life safety. According to statistics, from 2011 to 2013, an average of 600,000 people died in traffic accidents in my country every year, and 85% of them died due to massive hemorrhage at the initial stage of trauma. If the bleeding is controlled within 30 minutes after the accident, the survival rate of the injured can be increased by more than 40%. Blood is a natural microbial culture medium, and wound bleeding or oozing will also increase the chance of bacterial infection. Therefore, timel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/00A61L31/04A61L31/14
CPCA61L24/0036A61L24/08A61L31/042A61L31/146A61L2400/04C08L3/02
Inventor 杨飞李丹周啸田明明
Owner 江苏德威兰医疗器械股份有限公司
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