Sericin hydrogel beneficial to multi-tissue repair and preparation method thereof

A sericin and hydrogel technology, which is applied in medical science, bandages, etc., can solve the problems of unsatisfactory antibacterial properties of hydrogels, poor mechanical properties, and limitations of hydrogel applications.

Inactive Publication Date: 2020-06-05
苏州才豪电子科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the existing hydrogels are spray and smear gels, which have poor mechanical properties and greatly limit the application of hydrogels. When improving the mechanical properties of hydrogels, more chemical reagents will be used , there are biological toxicity and potential safety hazards; at the same time, the antibacterial properties of the existing hydrogels cannot meet our needs

Method used

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  • Sericin hydrogel beneficial to multi-tissue repair and preparation method thereof
  • Sericin hydrogel beneficial to multi-tissue repair and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] S1: Prepare materials:

[0055] Weigh polyoxyethylene, polyvinyl alcohol, ethylene glycol, sericin cocoon, polyethylene glycol, lithium bromide, sodium periodate, sodium alginate and carboxymethyl chitosan, and set aside;

[0056] Weigh antimicrobial peptides, gentian, Cortex Phellodendri, Fructus Cnidii and Ginkgo biloba, set aside;

[0057] S2: Prepare the first gel material:

[0058] Take polyoxyethylene, put it into ethylene glycol, ultrasonically disperse for 5 minutes, and then add deionized water to dissolve to obtain a polyoxyethylene solution; take polyvinyl alcohol, add deionized water and dimethyl sulfoxide to dissolve to obtain a polyvinyl alcohol solution Add the polyoxyethylene solution into the polyvinyl alcohol solution, mix and stir for 20 minutes, then refrigerate at 4°C for 2 hours, and then use an electron accelerator to irradiate and solidify to obtain the first gel material;

[0059] S3: Preparation of the second gel material:

[0060] Preparati...

Embodiment 2

[0069] S1: Prepare materials:

[0070] Weigh polyoxyethylene, polyvinyl alcohol, ethylene glycol, sericin cocoon, polyethylene glycol, lithium bromide, sodium periodate, sodium alginate and carboxymethyl chitosan, and set aside;

[0071] Weigh antimicrobial peptides, gentian, Cortex Phellodendri, Fructus Cnidii and Ginkgo biloba, set aside;

[0072] S2: Prepare the first gel material:

[0073] Take polyoxyethylene, put it into ethylene glycol, ultrasonically disperse for 8 minutes, and then add deionized water to dissolve to obtain a polyoxyethylene solution; take polyvinyl alcohol, add deionized water and dimethyl sulfoxide to dissolve to obtain a polyvinyl alcohol solution Add the polyoxyethylene solution into the polyvinyl alcohol solution, mix and stir for 25 minutes, then refrigerate at 5°C for 2.5 hours, and then use an electron accelerator to irradiate and solidify to obtain the first gel material;

[0074] S3: Preparation of the second gel material:

[0075] Prepara...

Embodiment 3

[0084] S1: Prepare materials:

[0085] Weigh polyoxyethylene, polyvinyl alcohol, ethylene glycol, sericin cocoon, polyethylene glycol, lithium bromide, sodium periodate, sodium alginate and carboxymethyl chitosan, and set aside;

[0086] Weigh antimicrobial peptides, gentian, Cortex Phellodendri, Fructus Cnidii and Ginkgo biloba, set aside;

[0087] S2: Prepare the first gel material:

[0088] Take polyoxyethylene, put it into ethylene glycol, ultrasonically disperse for 10 minutes, and then add deionized water to dissolve to obtain a polyoxyethylene solution; take polyvinyl alcohol, add deionized water and dimethyl sulfoxide to dissolve to obtain a polyvinyl alcohol solution Add the polyoxyethylene solution into the polyvinyl alcohol solution, mix and stir for 30 minutes, then refrigerate at 6°C for 3 hours, and then use an electron accelerator to irradiate and solidify to obtain the first gel material;

[0089] S3: Preparation of the second gel material:

[0090] Preparat...

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Abstract

The invention discloses sericin hydrogel beneficial to multi-tissue repair and a preparation method thereof. The hydrogel comprises a first gel material, a second gel material and a cross-linking agent, wherein the hydrogel is a double-layer structure with the first gel material as a base layer and the second gel material as an upper repair layer, wherein the first gel material comprises components such as polyoxyethylene, polyvinyl alcohol, ethylene glycol and the like, and a polyvinyl alcohol/polyoxyethylene composite layer (i.e. the first gel material) is obtained by composite preparation.The preparation method has reasonable process design and simple operation, not only optimizes structure of the hydrogel, designs the hydrogel as the double-layer structure with the first gel materialas the base layer and the second gel material as the repair layer, but also adds a traditional Chinese medicine combination material, sodium alginate, carboxymethyl chitosan and the like, so that thehydrogel has excellent sterilization and anti-inflammatory properties, can absorb wound exudate, provide a moist tissue contact environment, effectively promote wound healing, and has high practicability.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a sericin hydrogel beneficial to repairing multiple tissues and a preparation method thereof. Background technique [0002] Hydrogel is a kind of extremely hydrophilic three-dimensional network structure gel, which swells rapidly in water and can maintain a large volume of water without dissolving in this swollen state; due to the presence of cross-linked networks, hydrogel can swell And retain a large amount of water, the water absorption is closely related to the degree of crosslinking. [0003] Most of the existing hydrogels are spray and smear gels, which have poor mechanical properties and greatly limit the application of hydrogels. When improving the mechanical properties of hydrogels, more chemical reagents will be used , there are biological toxicity and potential safety hazards; at the same time, the antibacterial properties of the existing hydrogels cannot meet our ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J3/28C08J3/24C08J3/075C08L71/02C08L29/04C08L5/08C08L5/04C08L89/00
CPCA61L26/0014A61L26/0019A61L26/0023A61L26/0047A61L26/0066A61L26/008A61L26/0095A61L2300/252A61L2300/30A61L2300/404A61L2300/412A61L2300/45C08J3/075C08J3/246C08J3/28C08J2305/04C08J2305/08C08J2329/04C08J2371/02C08J2429/04C08J2471/02C08J2489/00C08L29/04C08L71/02C08L5/04C08L5/08C08L89/00
Inventor 不公告发明人
Owner 苏州才豪电子科技有限公司
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