A kind of aromatic ring ortho iodoalkanone and its synthesis method and application

Abstract

The invention discloses an aromatic ring ortho-iodoalkanone and its synthesis method and application. The structural formula of the aromatic ring ortho-iodoalkanone is as follows: A is an alkyl group or a 5-12-membered ring, R is an alkyl group, Halogen, alkoxy or aryl; R' is hydrogen, alkyl, alkoxy, aryl, substituted aryl or condensed aromatic ring, the synthesis steps include: in the presence of an oxidizing agent, react with an iodinating reagent to obtain the obtained The above-mentioned aromatic ring ortho-iodoalkanone. The invention uses cheap hypervalent iodine reagent as oxidant, can economically and efficiently synthesize aromatic ring ortho iodoalkanone, has simple, safe and easy-to-operate reaction process, high synthesis yield, and is suitable for industrialized production.

Description

technical field [0001] The invention belongs to the field of synthesis of organic intermediates, and in particular relates to an aromatic ring ortho iodoalkanone and its synthesis method and application. Background technique [0002] As an important class of organic synthesis intermediates, aryl iodide compounds are widely used in the synthesis of natural organic compounds and pharmaceutical active molecules. However, the iodination reaction on the aromatic ring is affected by the electrical and steric hindrance of the aromatic ring substituent, which makes the synthesis of the selective iodolation of the aromatic ring difficult. Researchers in this field have conducted a large number of experiments and confirmed that functional groups can induce selective aromatic ring iodination reactions. However, in the actual operation process of researchers, there are still many problems. The most important problem is that the iodination reaction is difficult to stop. In the single-io...

AI Technical Summary

Problems solved by technology

However, the iodination reaction on the aromatic ring is affected by the electrical and steric hindrance of the aromatic ring substituent, which makes the synthesis of aromatic ring selective iodination difficult.

Researchers in this field have conducted a large number of experiments and confirmed that functional groups can induce selective aromatic ring iodination reactions, but in the actual operation process, there are still many problems. The most important problem is that the iodination reaction is difficult to stop. In the single-iodination stage, the final product is multi-iodination products of aromatic rings, which cannot be used as intermediates for synthesis

Images