Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of decarbonization filter device and the method for preparing aminolevulinic acid hydrochloride

A filter device and filter plate technology, applied in the separation method, filter separation, filter circuit, etc., can solve the problems of affecting the progress, poor filtration efficiency, slow speed, etc., and achieve the effect of good quality, short process and simple operation steps

Active Publication Date: 2021-10-01
SHANGHAI WANXIANG PHARMA
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Since the level of the feed inlet is lower than that of the discharge outlet, the mixed solution to be treated entering the feed inlet will have a lower filtration efficiency due to its own gravity due to the filtering operation from bottom to top. Poor, slow speed, this time will inevitably affect the entire progress, so it is necessary to propose a new technical solution to solve the above problems

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of decarbonization filter device and the method for preparing aminolevulinic acid hydrochloride
  • A kind of decarbonization filter device and the method for preparing aminolevulinic acid hydrochloride
  • A kind of decarbonization filter device and the method for preparing aminolevulinic acid hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1: a kind of decarbonization filtering device, such as figure 1 As shown, it includes a frame 1, and a casing 2 fixedly installed on the frame 1 with an open upper end and a hollow interior. The casing 2 is in the form of a cylindrical barrel, and a cover 3 is detachably connected to the opening. The above-mentioned cover body 3 can be sealed and closed on the casing 2, and the casing 2 is provided with a material inlet 5 and a material outlet 6 sequentially from bottom to top.

[0049] like figure 1 As shown, in order to increase the retention of activated carbon, a filter plate 7 arranged horizontally is rotatably connected to the housing 2 . The filter plate 7 is disc-shaped, and there is a gap between it and the inner wall of the housing 2 . There is a filter cavity 8 between the filter plate 7 and the feed port 5. The filter plate 7 communicates with a central tube 9 on the side away from the filter cavity 8, and the central tube 9 communicates with a p...

Embodiment 2

[0056] Embodiment 2: a kind of method for preparing aminolevulinic acid hydrochloride comprises the following steps:

[0057] Step 1. Add 5-phthalimide levulinic acid to 400ml of 5mol / L hydrochloric acid solution, reflux for 4 hours, cool slightly, add activated carbon, and decolorize through the decarbonization filter device of Example 1 at 80°C. Cool to 5°C and filter. Concentrate the filtrate, cool at 5°C, precipitate crystals, filter, and vacuum-dry the filter cake for 4 hours under a vacuum of 0.8 MPa to obtain the crude product.

[0058] Wherein, the molecular formula of 5-phthalimide levulinic acid: C13H11O5N, its chemical structural formula is as follows:

[0059]

[0060] Step 2, finish processing: add the water (60 ℃) of the same quantity as crude product feeding amount to dissolve crude product, filter, add the acetone of 50wt% of crude product feeding amount, cool to room temperature (20 ℃), place 4 ℃, after 3 hours put The solid-liquid mixture was filtered, a...

Embodiment 3

[0063] Embodiment 3: a kind of method for preparing aminolevulinic acid hydrochloride comprises the following steps:

[0064] Step 1. Add 5-phthalimide levulinic acid into 500ml of 8mol / L hydrochloric acid solution, reflux for 8 hours, cool slightly, add activated carbon, and decolorize through the decarbonization filter device of Example 1 at 90°C. Cool to 15°C and filter. Concentrate the filtrate, cool at 15°C, precipitate crystals, filter, and vacuum-dry the filter cake for 5 hours under a vacuum of 1.0 MPa to obtain the crude product.

[0065] Step 2, finishing: add the water (75 ℃) of the same quantity as crude product feeding amount to dissolve crude product, filter, add the acetone of 50wt% of crude product feeding rate, cool to room temperature (20 ℃), place 8 ℃, after 4 hours put The solid-liquid mixture was filtered, and the obtained crystal was vacuum-dried for 15 hours to obtain the fine product of aminolevulinic acid hydrochloride.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a decarbonization filter device and a method for preparing aminolevulinic acid hydrochloride, belonging to the technical field of aminolevulinic acid hydrochloride production. A decarbonization filter device includes a shell, a cover, the shell has a filter plate and a central tube, and a plurality of filter elements are connected to the central tube; a bracket is arranged on the inner wall of the shell, a snap-fit ​​ring and a motor are rotatably connected to the central tube, The output shaft of the motor coincides with the central axis of the central tube; the housing has a baffle connected to the bearing of the central tube, and the baffle is fixed on the inner wall of the housing; there is a filter element 2 in the housing, which is connected to the main pipe, and one end of the main pipe is sealed. The other end is connected to the outlet. Its preparation method is to add 5-phthalimide levulinic acid to the hydrochloric acid solution to reflux, add activated carbon to decolorize slightly, and filter; the concentrated filtrate is cooled to precipitate crystals, filter, and the filter cake is vacuum-dried, and then washed with acetone / Water recrystallization to obtain the fine product of aminolevulinic acid hydrochloride. The invention uses centrifugal force to accelerate filtration, has high decarbonization efficiency, and obtains aminolevulinic acid hydrochloride with high yield and good quality.

Description

technical field [0001] The invention relates to the technical field of production of aminolevulinic acid hydrochloride, more specifically, it relates to a decarbonization filter device and a method for preparing aminolevulinic acid hydrochloride. Background technique [0002] Aminolevulinic acid hydrochloride (abbreviation: 5-ALA, ALA), is a second-generation photosensitizer developed in recent years, and is a precursor of hemoglobin synthesis in vivo. [0003] A study conducted by several authoritative institutions in China shows that the treatment of genital warts with aminolevulinic acid hydrochloride can effectively reduce the recurrence rate of the disease while obtaining a high cure rate. The study was jointly carried out by 5 medical institutions including Peking University First Hospital. During the 1-year study period, a total of 453 patients with condyloma acuminatum were included. The results showed that the wart removal rate of ALA was 98.44%, and there were no ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B01D36/02B01D15/00C07C227/18C07C229/22
CPCB01D15/00B01D36/02C07C227/18C07C229/22
Inventor 袁相富胡志奇张崇东
Owner SHANGHAI WANXIANG PHARMA