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Application of dennd1c as a molecular marker in diagnosis and treatment of abdominal aortic aneurysm

An abdominal aortic aneurysm and molecular beacon technology, applied in the application field of molecular markers, can solve the problem that the pathogenesis of abdominal aortic aneurysm is not completely clear and the like

Active Publication Date: 2020-10-27
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the specific pathogenesis of abdominal aortic aneurysm is not completely clear. Existing reports have shown that its pathogenesis is closely related to factors such as genetic factors, inflammation, protease degradation, and smooth muscle cell apoptosis. different mutations

Method used

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  • Application of dennd1c as a molecular marker in diagnosis and treatment of abdominal aortic aneurysm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1D

[0056] Example 1 Correlation Study of DENND1C Gene Expression and Abdominal Aortic Aneurysm

[0057] 1. Animals and Handling

[0058] Male wild-type C57BL / 6J was obtained from Jackson Laboratories (Bar Harbor, Me). All mice were housed in pathogen-free isolation cages as littermate controls. Mice received a normal laboratory diet. Mice aged 10-12 weeks were subcutaneously injected with normal saline or angiotensin II (AngII) using Alzet osmotic minipumps (2004, Durect Corporation), and the injection dose was 1000ng.kg-1.min-1 (Sigma-Aldrich , St. Louis, MO). AAA mice and normal control mice were anesthetized with 10% chloral hydrate, and sterilized by soaking in 75% alcohol for 2 minutes. The chest cavity and abdominal cavity were opened, the organs were pushed aside, the heart and aorta were exposed, and the blood was sucked away with gauze. Carefully cut the full length of the heart and aorta up to the bifurcation of the abdominal aorta, and immediately put it in 0.01M ...

Embodiment 2

[0074] Example 2 The effect of DENND1C gene expression on the function of aortic smooth muscle cells

[0075] 1. Interfering with gene expression

[0076] 1. Culture of human aortic smooth muscle cells

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Abstract

The invention provides application of DENND1C as a molecular marker for diagnosing and treating abdominal aortic aneurysm. The research shows that the expression of the DENND1C in healthy control andabdominal aortic aneurysm patients is obviously different, so that the DENND1C is considered to be capable of being used as the molecular marker for diagnosing the abdominal aortic aneurysm. In addition, the invention also discloses application of the DENND1C to preparation of medicine for treating the abdominal aortic aneurysm.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of DENND1C, in particular to the application of DENND1C as a molecular marker for diagnosis and treatment of abdominal aortic aneurysm. Background technique [0002] Abdominal aortic aneurysm (AAA) is a common life-threatening arterial degenerative disease, which is defined as the continuous expansion of the three-layer structure of the arterial wall in the abdominal aortic segment to 1.5 of the diameter of the abdominal aorta at the renal artery. more than double. Among the causes of death of men over 65 years old, AAA ranks 10th, and more than 10% of them are troubled by it, and the incidence of AAA in western countries has an increasing trend year by year. In my country, with the aging of the population and the change of diet structure, the incidence of AAA is on the rise, and it has become one of the major diseases that seriously threaten the life and health of our pe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886A61K45/00A61P35/00
CPCA61K45/00A61P35/00C12Q1/6886C12Q2600/158
Inventor 张慧李方达陈思良杨丹郑月宏
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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