3D voxel printing device based on cell soft spheres and method thereof

A technology for printing devices and cells, applied in the field of 3D bioprinting, can solve problems such as difficulty in realization and difficulty in independent molding of printed structures.

Active Publication Date: 2020-06-12
杭州济扶科技有限公司
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  • Application Information

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Problems solved by technology

However, in the 3D bioprinting based on protein fibers, it is difficult to independently shape the printed structure, and it is difficult to achieve 3D...

Method used

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  • 3D voxel printing device based on cell soft spheres and method thereof
  • 3D voxel printing device based on cell soft spheres and method thereof
  • 3D voxel printing device based on cell soft spheres and method thereof

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Embodiment Construction

[0023] Embodiments of the present invention will be described in detail below. It should be emphasized that the following description is only exemplary and not intended to limit the scope of the invention and its application.

[0024] It should be noted that when an element is referred to as being “fixed” or “disposed on” another element, it may be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element. In addition, the connection can be used for fixation as well as for coupling or communication.

[0025] It is to be understood that the terms "length", "width", "top", "bottom", "front", "rear", "left", "right", "vertical", "horizontal", "top" , "bottom", "inner", "outer" and other indicated orientations or positional relationships are based on the orientations or positional relationships shown in ...

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Abstract

The invention discloses a 3D voxel printing device based on cell soft spheres and a method thereof. The device comprises a water phase input part, an oil phase input part and a microfluidic microtube,wherein the water phase input part inputs an extracellular matrix material loaded with cells, namely bio-ink, into the microfluidic microtube; and the oil phase input part synchronously inputs a low-viscosity and low-boiling-point oil phase meeting set requirements into the microfluidic microtube. The extracellular matrix material loaded with the cells is separated into monodisperse microdropletsembedded with the cells through an oil phase, the microdroplets are gelled into cell soft spheres in the flowing process in the microtube, the cell soft spheres are sequentially shot onto a substrateby utilizing rapid expansion and volatilization of the oil phase at an outlet of the microfluidic microtube, and the cell soft spheres are adhered together through an incompletely gelled ink material. An in-vitro model capable of highly reducing the human organ or tissue structure and the cell microenvironment can be printed under the condition that a printing material does not contain a biological inert material for assistance.

Description

technical field [0001] The invention relates to 3D bioprinting, in particular to a 3D voxel printing device and method based on soft cell spheres. Background technique [0002] Bio-ink cell soft scaffold materials are derived from mammalian tissue extraction materials, rich in protein fibers, which can provide human cells with an in vivo-like matrix environment, and are an ideal matrix material for tissue preparation in vitro. However, in 3D bioprinting based on protein fibers, it is difficult to independently shape the printed structure, and it is difficult to achieve 3D printing of biological soft tissues without the aid of biologically inert materials that only contain cells and corresponding extracellular matrix materials. Contents of the invention [0003] The main purpose of the present invention is to overcome the above-mentioned technical defects and provide a 3D voxel printing device and method based on soft cell spheres. [0004] To achieve the above object, the...

Claims

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Application Information

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IPC IPC(8): C12M3/00B33Y30/00C12N5/071
CPCC12M23/16C12M33/00B33Y30/00C12N5/0671C12N2513/00
Inventor 马少华王好谦
Owner 杭州济扶科技有限公司
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