Novel 2019-nCoV coronavirus rapid detection immunochromatographic test strip

A technology of 2019-ncov and immunochromatographic test strips, which is applied in the field of medical devices, can solve the problems of inability to meet the detection needs of suspected cases, low throughput of nucleic acid detection instruments, and high professional requirements for nucleic acid detection, achieving high production capacity, low professional requirements, The effect of high positive detection rate

Pending Publication Date: 2020-06-12
GUANGZHOU WONDFO BIOTECH
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

The 2019-nCoV new coronavirus nucleic acid detection kit was first successfully developed and put into use, but its detection takes at least 40 minutes, and the throughput of nucleic acid detection equipment is relatively small, which is far from me

Method used

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  • Novel 2019-nCoV coronavirus rapid detection immunochromatographic test strip
  • Novel 2019-nCoV coronavirus rapid detection immunochromatographic test strip
  • Novel 2019-nCoV coronavirus rapid detection immunochromatographic test strip

Examples

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Effect test

Embodiment 12019

[0037] Example 1 2019-nCoV novel coronavirus rapid detection immunochromatographic test strip

[0038] The 2019-nCoV new coronavirus rapid detection immunochromatographic test strip of this embodiment includes a base plate 8, and a sample pad 1, a binding pad 2, a coating film 3 and a water-absorbent pad 4 that are sequentially arranged on the base plate 8 (absorbent paper), the binding pad 2 is coated with 2019-nCoV recombinant structural protein-fluorescent marker and goat anti-chicken IgY antibody-fluorescent marker, and the coating film 3 includes the first parallel set and spaced apart. Detection line 5, second detection line 6 and control line 7, the first detection line 5 is coated with anti-human μ chain antibody, the second detection line 6 is composed of anti-human IgG antibody, and the control line 7 is coated with Chicken IgY. In this embodiment, the second detection line 6 is between the first detection line 5 and the control line 7 . see figure 1 .

[0039] I...

Embodiment 2

[0051] The preparation of the 2019-nCoV novel coronavirus detection test strip described in this example is the same as in Example 1, except that the position of the detection line for detecting specific antibody IgM and specific antibody IgG is reversed, that is, the first detection line is at 2 Between the detection line and the control line.

Embodiment 3

[0053] The preparation of the 2019-nCoV new coronavirus detection test strip described in this example is the same as in Example 1, except that the first detection line 5 for detecting the specific antibody IgM and the second detection line for detecting the specific antibody IgG The distance between 6 is the conventional 3.5 mm, and the distance between the specific antibody IgG detection line 6 and the control line 7 is 4.5 mm.

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Abstract

The invention discloses a novel 2019-nCoV coronavirus rapid detection immunochromatographic test strip. A sample pad, a combination pad, a nitrocellulose membrane and a water absorption pad are sequentially bonded on a bottom plate in a mutual lap joint manner; a 2019-nCoV recombinant structural protein-fluorescent marker and a goat anti-chicken IgY antibody-fluorescent marker are sprayed on the combination pad; the nitrocellulose membrane is provided with a first detection line coated with an anti-human mu chain antibody, a second detection line coated with an anti-human IgG antibody, and a control line coated with chicken IgY, and the detection lines and the control line are spaced from each other. The novel 2019-nCoV coronavirus detection immunochromatographic test strip can be used forrapidly detecting a specific antibody IgM or IgG of a patient,has the advantages of being rapid, accurate and high in positive detection rate, is suitable for being used for rapid detection and timely restraining propagation and spreading of 2019-nCoV novel coronas at present, and enables patients to be treated according to symptoms.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to an immunochromatographic test strip for rapid detection of 2019-nCoV novel coronavirus. Background technique [0002] At present, there is no specific treatment for Corona Virus Disease 2019 (COVID-19), but many symptoms can be treated and should be treated according to the clinical condition of the patient. Each case of COVID-19 must collect acute phase respiratory specimens (throat swab, nasal swab, nasopharyngeal aspirate, deep cough sputum, respiratory aspirate, bronchial lavage fluid, alveolar lavage fluid, lung biopsy specimens) etc.) and blood samples. Respiratory samples are mainly used for nucleic acid detection and antigen detection, and serum samples are mainly used for COVID-19 virus-specific antibody IgM or IgG detection. Among them, the specific antibody IgM is the earliest antibody in the initial humoral immune response, appearing in about a week. The detection of...

Claims

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Application Information

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IPC IPC(8): G01N33/569G01N33/558G01N33/533
CPCG01N33/533G01N33/558G01N33/56983G01N2333/165
Inventor 黄岭芳杜嘉铭杨斌李凯
Owner GUANGZHOU WONDFO BIOTECH
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