Extraction and purification device and method utilizing magnetic extraction material

A purification device and extraction technology, which is applied in the field of in vitro clinical testing sample processing, can solve problems such as long time, large error, and high difficulty

Pending Publication Date: 2020-06-16
苏州艾捷博雅生物电子科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, high-precision analytical instruments have relatively strict requirements on the pretreatment of test samples. In addition, due to the complexity of biological test samples, the difficulty of sample pretreatment is relatively high, and there are still the following problems to be solved: (1) Sample pretreatment steps Numerous, complex processes, high requirements for personnel skills; (2) non-intelligent, large human interference factors, easy to cause unstable results, large errors, and high error rates; (3) long experiment cycle, or low processing efficiency, cost high
However, the disadvantages of this method are: 1) it takes a long time for the target substance in the liquid sample to reach adsorption equilibrium in the extraction material and the solution; 2) the process of

Method used

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  • Extraction and purification device and method utilizing magnetic extraction material
  • Extraction and purification device and method utilizing magnetic extraction material
  • Extraction and purification device and method utilizing magnetic extraction material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Embodiment 1 pipetting module

[0087] The structural diagram of the pipetting module of this embodiment is as follows: figure 1 As shown, the pipetting module 1 includes a syringe pump 2 and a second guide rail 3, the second guide rail 3 is connected and can drive the syringe pump 2 to move up and down. The bottom of the syringe pump 2 is provided with a first interface 201. When the pipetting module 1 moves above the pipetting head station module 7, the syringe pump 2 moves downward along the second guide rail 3, so that the pipetting head station module 7 The upper opening of the pipetting head 701 can be tightly connected to the first interface 201 of the syringe pump 2, and moves to the reagent station module 9 and the extraction station module 8 with the pipetting module 1, and the syringe pump 2 provides pressure to make the pipetting The liquid head 701 sucks or discharges reagents.

[0088] The syringe pump 2 provides a negative pressure for the pipetting hea...

Embodiment 2

[0091] Embodiment 2 station module

[0092] The station module structure of the present embodiment is as figure 2 As shown, the station module is arranged under the pipetting module 1, including a pipette head station module 7, an extraction station module 8 and three reagent station modules 9, the pipette head station module 7, the extraction station module The position module 8 and the reagent station module 9 are arranged sequentially along the moving direction of the first guide rail 6 , that is, the position of the station module can correspond to the position of the pipetting module 1 up and down. The three reagent station modules 9 are respectively used to hold the sample solution, the eluent and the finished product solution. The finished solution is the liquid formed after the sample solution is extracted and / or purified, and can be directly used in subsequent high-precision testing instruments.

[0093] The station module includes a turntable 10, a transmission me...

Embodiment 3

[0101] Embodiment 3 extraction and purification device

[0102] In this embodiment, the pipetting module 1 of Embodiment 1, the extraction station module 8 , the reagent station module 9 and the pipetting head station module 7 of Embodiment 2 are used.

[0103] The structure of the extraction and purification device of the present embodiment is as follows: Figure 4 As shown, the first guide rail 6 is arranged above the pipetting module 1, and the top of the second guide rail 3 is detachably fixed on the first guide rail 6. The extraction and purification device of this embodiment includes three pipetting modules 1, each The pipetting modules 1 are sequentially arranged on the first guide rail 6 . The first guide rail 6 is an annular guide rail, and each pipetting module 1 performs circular motion on the annular guide rail, so as to facilitate the continuous extraction operation.

[0104] The station module is arranged below the liquid pipetting module 1 and includes a pipet...

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Abstract

The invention relates to an extraction and purification device and method. The extraction and purification device comprises at least one pipetting module, at least five station modules, a waste liquidbox, a waste box and a first guide rail; the pipetting module or the station module can move on the first guide rail, the station module is arranged below the pipetting module and comprises at leastone pipetting head station module, at least one extraction station module and at least three reagent station modules, and the station module, the waste liquid box and the waste box are arranged in themoving direction of a first guide rail; an extraction material is arranged in the extraction station module, the extraction station module comprises a stirrer and a power supply, and the power supplycontrols the stirrer to attract, fix and stir an extraction material; the pipetting module comprises a liquid driving device and a second guide rail, and the liquid driving device can move up and down on the second guide rail. The volume of the extraction material is not less than 1 cubic millimeter, and the surface of the extraction material has a mesoporous structure and has adsorption or exchange capacity.

Description

technical field [0001] The invention belongs to the field of in vitro clinical testing sample processing, and in particular relates to an extraction and purification device and method. Background technique [0002] In the field of clinical testing and precision medicine, instruments such as mass spectrometry, chromatography, or liquid chromatography-mass spectrometry have advantages in sensitivity, versatility, analysis speed, and simultaneous detection of multiple indicators. These high-precision analytical instruments can be used in clinical biochemistry, clinical Immunological testing, clinical microbiological testing, proteomics, metabolomics research and other fields. However, high-precision analytical instruments have relatively strict requirements on the pretreatment of test samples. In addition, due to the complexity of biological test samples, the difficulty of sample pretreatment is relatively high, and there are still the following problems to be solved: (1) Sampl...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/28G01N30/06G01N30/14B01D15/42B01D15/10B01J20/30
CPCB01J20/06B01J20/10B01D15/10B01D15/424G01N30/06G01N30/14B01J20/08B01J20/26B01J20/28009G01N2030/062
Inventor 汪群杰冯俊雄张亚昆王鹏飞王开祥
Owner 苏州艾捷博雅生物电子科技有限公司
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