Metabonomics-based early diagnosis marker for chronic obstructive pulmonary disease and application thereof

A diagnostic marker and metabolomics technology, applied in the field of COPD diagnostic markers, to achieve accurate distinction, high clinical use and promotion value
CN111289736AInactive Publication Date: 2020-06-16PEKING UNIV +1
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
PEKING UNIV
Publication Date
2020-06-16
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses a metabonomics-based diagnosis marker for chronic obstructive pulmonary disease and application thereof. The diagnosis marker comprises the following 28 blood plasma metabolismmarkers: phosphatidylcholine PC 16:1-36:3, phosphatidylcholine PC 26:0-22:4, phosphatidylcholine PC 26:0-22:3, phosphatidylcholine PC 47:5e, phosphatidylcholine PC 44:11e, phosphatidylcholine PC 16:0-24:5, phosphatidylcholine PC 20:2-20:3, phosphatidylcholine PC 40:10, phosphatidylcholine PC 38:9e, phosphatidylcholine PC 18:1-20:4, phosphatidylcholine PC 16:0-20:3, phenylacetaldehyde, dihydrouracil, nicotinamide, 4-methoxycinnamic acid, ketovaline, threonine, DL-3-aminoisobutyric acid, pyruvic acid, stachyose, caffeic acid, N, N-dimethylaniline, maltotriose, D(-)-gulonate-gamma-lactone, and L-asparaginase. The marker provided by the invention has good classification on metabolome data of patients suffering chronic obstructive pulmonary disease and healthy people, and can accurately distinguish the patients suffering chronic obstructive pulmonary disease from the healthy people.
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Description

[0001] The present invention claims the priority of Chinese patent application CN202010078213.1, and the contents of the description, drawings and claims of the priority document are incorporated into the specification of the invention in full and are taken as a part of the original description of the specification of the invention. The applicant further declares that the applicant has the right to modify the specification and claims of the present invention based on the priority document. Technical field

[0002] The invention belongs to the field of clinical laboratory diagnosis, and specifically relates to a COPD diagnostic marker based on metabolomics and its application. Background technique

[0003] Chronic Obstructive Pulmonary Disease (COPD), or chronic obstructive pulmonary disease, is an important chronic respiratory disease that seriously endangers human health. An epidemiological survey in my country shows that the prevalence of COPD among people over 40 years old is 1...

Claims

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