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Metabonomics-based early diagnosis marker for chronic obstructive pulmonary disease and application thereof

A diagnostic marker and metabolomics technology, applied in the field of COPD diagnostic markers, to achieve accurate distinction, high clinical use and promotion value

Inactive Publication Date: 2020-06-16
PEKING UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few reports on the application of liquid phase mass spectrometry metabolomics technology in COPD and acute exacerbation of COPD

Method used

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  • Metabonomics-based early diagnosis marker for chronic obstructive pulmonary disease and application thereof
  • Metabonomics-based early diagnosis marker for chronic obstructive pulmonary disease and application thereof
  • Metabonomics-based early diagnosis marker for chronic obstructive pulmonary disease and application thereof

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Experimental program
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Embodiment 1

[0027] 1. Research object

[0028] The study included plasma samples from 48 patients with stable COPD and 48 patients with acute COPD from Peking University Third Hospital, and 48 healthy patients with normal lung function and no chronic heart and lung diseases. Volunteer plasma samples.

[0029] 2. Non-targeted metabolomics analysis of plasma using liquid chromatography-mass spectrometry technology

[0030] All plasma samples were centrifuged and stored in a refrigerator at -80°C. Plasma samples were taken during the research, and after sample pretreatment, non-targeted metabolomics analysis was performed using a high performance liquid chromatography-mass spectrometer to obtain the original metabolic fingerprint of the sample containing chromatographic and mass spectral information. The specific operations are as follows:

[0031] 2.1 Instruments and reagents

[0032] Experimental instruments include: high performance liquid chromatography mass spectrometry (U3000 / QEaxctive, Therm...

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Abstract

The invention discloses a metabonomics-based diagnosis marker for chronic obstructive pulmonary disease and application thereof. The diagnosis marker comprises the following 28 blood plasma metabolismmarkers: phosphatidylcholine PC 16:1-36:3, phosphatidylcholine PC 26:0-22:4, phosphatidylcholine PC 26:0-22:3, phosphatidylcholine PC 47:5e, phosphatidylcholine PC 44:11e, phosphatidylcholine PC 16:0-24:5, phosphatidylcholine PC 20:2-20:3, phosphatidylcholine PC 40:10, phosphatidylcholine PC 38:9e, phosphatidylcholine PC 18:1-20:4, phosphatidylcholine PC 16:0-20:3, phenylacetaldehyde, dihydrouracil, nicotinamide, 4-methoxycinnamic acid, ketovaline, threonine, DL-3-aminoisobutyric acid, pyruvic acid, stachyose, caffeic acid, N, N-dimethylaniline, maltotriose, D(-)-gulonate-gamma-lactone, and L-asparaginase. The marker provided by the invention has good classification on metabolome data of patients suffering chronic obstructive pulmonary disease and healthy people, and can accurately distinguish the patients suffering chronic obstructive pulmonary disease from the healthy people.

Description

[0001] The present invention claims the priority of Chinese patent application CN202010078213.1, and the contents of the description, drawings and claims of the priority document are incorporated into the specification of the invention in full and are taken as a part of the original description of the specification of the invention. The applicant further declares that the applicant has the right to modify the specification and claims of the present invention based on the priority document. Technical field [0002] The invention belongs to the field of clinical laboratory diagnosis, and specifically relates to a COPD diagnostic marker based on metabolomics and its application. Background technique [0003] Chronic Obstructive Pulmonary Disease (COPD), or chronic obstructive pulmonary disease, is an important chronic respiratory disease that seriously endangers human health. An epidemiological survey in my country shows that the prevalence of COPD among people over 40 years old is 1...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/53G01N30/02G01N30/86
CPCG01N30/02G01N30/8686G01N33/5308G01N2800/122G01N2800/7066
Inventor 尹玉新周骏拓李秋钰
Owner PEKING UNIV
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