Sodium alginate-silver-loaded graphene composite film with antibacterial and wound healing functions and its application

A graphene composite and sodium alginate technology, applied in bandages, absorbent pads, medical science and other directions, can solve the problems of single wound dressings, inability to take into account antibacterial and wound healing functions at the same time, etc., to promote wound healing, High potential for clinical and market applications, low cytotoxicity

Active Publication Date: 2020-05-22
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides sodium alginate-silver-loaded graphene composite film with antibacterial and wound healing functions and a preparation method thereof for solving the shortcomings of the above-mentioned prior art, and uses it as a wound dressing, It aims to solve the shortcomings of the existing trauma wound dressings, which have a single function and cannot take into account the functions of antibacterial and wound healing at the same time

Method used

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  • Sodium alginate-silver-loaded graphene composite film with antibacterial and wound healing functions and its application
  • Sodium alginate-silver-loaded graphene composite film with antibacterial and wound healing functions and its application
  • Sodium alginate-silver-loaded graphene composite film with antibacterial and wound healing functions and its application

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Effect test

Embodiment 1

[0030] The present embodiment carries out the preparation of sodium alginate-silver-loaded graphene composite membrane according to the following steps:

[0031] a. Take 200mg of graphene oxide flakes and add them to 200mL of distilled water. After ultrasonic dispersion, add 2g of polystyrene sodium sulfate, stir to dissolve, then add 200μL of hydrazine hydrate, heat to 100°C and reflux for 24 hours. The obtained product is suction filtered, After lyophilization, the reduced graphene oxide-polystyrene sodium sulfate composite was obtained;

[0032] b. Add the reduced graphene oxide-polystyrene sodium sulfate complex obtained in step a into 50mL of water, mix well, put it into a 100mL single-necked bottle, heat to 60°C, and then add 5mL of 0.02mol The silver nitrate solution of / L is slowly added in the single-neck bottle through the double syringe pump at the speed of 0.5mL / h, after adding, continue to stir at constant temperature for 10h, centrifuge and remove the supernatant...

Embodiment 2

[0049] This embodiment prepares sodium alginate-silver-loaded graphene composite film according to the following steps:

[0050] a. Take 300mg of graphene oxide flakes and add them to 200mL of distilled water. After ultrasonic dispersion, add 2g of polystyrene sodium sulfate, stir to dissolve, then add 200μL of hydrazine hydrate, heat to 100°C and reflux for 24 hours. The obtained product is suction filtered, After lyophilization, the reduced graphene oxide-polystyrene sodium sulfate composite is obtained;

[0051] b. Add the reduced graphene oxide-polystyrene sodium sulfate complex obtained in step a into 100mL of water, mix well, put it into a 250mL single-necked bottle, heat to 60°C, and then add 10mL of / L of silver nitrate solution was slowly added to the single-necked bottle through a double syringe pump at a rate of 0.5mL / h, and continued to stir at a constant temperature for 10 hours after the addition, centrifuged and removed the supernatant to obtain a silver-loaded ...

Embodiment 3

[0056] This embodiment prepares sodium alginate-silver-loaded graphene composite film according to the following steps:

[0057] a. Take 200mg of graphene oxide flakes and add them to 300mL of distilled water. After ultrasonic dispersion, add 2g of polystyrene sodium sulfate, stir to dissolve, then add 400μL of hydrazine hydrate, heat to 100°C and reflux for 24 hours. The obtained product is suction filtered, After lyophilization, the reduced graphene oxide-polystyrene sodium sulfate composite is obtained;

[0058] b. Add the reduced graphene oxide-polystyrene sodium sulfate complex obtained in step a into 100mL of water, mix well, put it into a 250mL single-necked bottle, heat to 60°C, and then add 10mL of / L of silver nitrate solution was slowly added to the single-necked bottle through a double syringe pump at a rate of 0.5mL / h, and continued to stir at a constant temperature for 10 hours after the addition, centrifuged and removed the supernatant to obtain a silver-loaded ...

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Abstract

The invention discloses a sodium alginate / silver loaded graphene composite film having bacterium resistance and wound healing promotion functions and application thereof. The composite film is characterized by being prepared through the following steps: uniformly mixing a silver loaded graphene solution and a sodium alginate solution, spraying and assembling. The composite film provided by the invention is simple in preparation method, simultaneously has bacterium resistance and wound healing promotion functions, and achieves an obvious effect when being used as a wound dressing, thereby having great clinical application potentials.

Description

technical field [0001] The invention relates to a sodium alginate composite material, in particular to a sodium alginate-silver-loaded graphene composite film with functions of promoting wound healing and antibacterial function and a preparation method thereof. Background technique [0002] Sodium alginate is a natural polymer compound, mainly derived from brown algae in the ocean. Sodium alginate is a block copolymer composed of two unit structures of β-D-mannuronic acid and α-L-guluronic acid residues through α-1-4 glycosidic bonds. As a natural substance of polysaccharides, sodium alginate polymer material has excellent characteristics such as good biocompatibility, water absorption, oxygen permeability, non-toxicity and film-forming property. Based on this, the application of composite films prepared by mixing sodium alginate films with other polymers in antibacterial and trauma wound dressings has attracted the attention of researchers, and some alginate wound dressing...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J5/18C08L5/04C08K9/10C08K3/04C08K3/08A61L15/18A61L15/28A61L15/46
CPCA61L15/18A61L15/28A61L15/46A61L2300/104A61L2300/404C08J5/18C08J2305/04C08K3/04C08K3/08C08K9/10C08K2003/0806C08L2203/16C08L5/04
Inventor 陆杨闫旭薛敬哲胡康棣徐维平潘晓锋李飞宋永红吴亚东苏杨何涛刘建楠
Owner HEFEI UNIV OF TECH
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