Pyridine-2-aryl-3-sulfonamide compound and its synthesis method and application

A technology of sulfonamides and synthesis methods, applied in the preparation of anti-tumor drugs or tubulin polymerization inhibitors, pyridine-2-aryl-3-sulfonamides and their synthesis fields, can solve the problem of high structural toxicity, Toxic side effects, drug resistance and other issues
CN111320575BActive Publication Date: 2022-04-05ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2022-04-05

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Abstract

The invention discloses a pyridine-2-aryl-3-sulfonamide compound, its synthesis method and its application in the preparation of antitumor drugs or tubulin polymerization inhibitors. The pyridine-2-aryl-3-sulfonamide compound of the present invention has the general structural formula (I), X, Y, Z are taken from C or N atom, R 1 Represents a monosubstituted or polysubstituted group; R 2 Represents a monosubstituted or polysubstituted group; R 3 Represents hydrogen or benzenesulfonyl substituted by different C1-5 alkoxy groups. The application of pyridine-2-aryl-3-sulfonamide compounds in the preparation of medicines is used as an active ingredient for the preparation of antitumor medicines or tubulin polymerization inhibitors. The antitumor drugs are anti-colon cancer, anti-breast cancer, anti-liver cancer, anti-lung cancer, anti-gastric cancer or anti-pancreatic cancer drugs.
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Description

technical field

[0001] The invention relates to the technical field of tubulin polymerization inhibitors, in particular to pyridine-2-aryl-3-sulfonamide compounds and their synthesis methods and applications for the preparation of antitumor drugs or tubulin polymerization inhibitors. Background technique

[0002] As an important component of eukaryotic cells, microtubules participate in the construction of the cytoskeleton and play an important role in maintaining cell shape, signal transduction, material transport and cell division. Microtubules are mainly assembled by α-tubulin and β-tubulin heterodimers, and are hollow tubular after assembly. In addition, γ-tubulin, although not a component of microtubules, is involved in the assembly of microtubules. Microtubules have certain dynamic characteristics, including polymerization and depolymerization processes. Microtubules aggregate into spindles in the early stage of mitosis, which can pull chromosomes to move to the two ...

Claims

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