Ophthalmic pharmaceutical composition, ophthalmic pharmaceutical box and medicinal application of pharmaceutical composition and pharmaceutical box
A composition and ophthalmic technology, applied in the field of medicine, can solve problems such as complicated operation, achieve the effects of good stability and prolong shelf life
Active Publication Date: 2020-07-03
SHENYANG XINGQI PHARM CO LTD
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- Abstract
- Description
- Claims
- Application Information
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Problems solved by technology
However, whether it is a non-biodegradable implant or a biodegradable implant, it needs to be implanted into the eye through surgery or a special drug delivery device (such as Ozurdex with a special injection device). must be painful
Method used
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Examples
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Effect test
preparation example 1-8
[0054] Preparation Example 1-8 Preparation of Ophthalmic Preparations 1-8
[0055] According to the formula in Table 1, weigh the liquid base and the active pharmaceutical ingredient in a beaker and stir evenly to obtain the mixture; fill the mixture into pre-filled syringes, each filling volume is 0.1mL, to obtain the ophthalmic preparation 1- 8.
[0056] Table 1
[0057]
preparation example 9
[0058] Preparation Example 9 Preparation of Ophthalmic Preparation 9
[0059] Weigh 7.5 g of ethyl salicylate, add 2.5 g of dexamethasone therein and mix evenly to obtain ophthalmic preparation 9.
preparation example 10
[0060] Preparation Example 10 Preparation of Ophthalmic Preparation 10
[0061] Weigh 20.0 g of methyl salicylate, add 0.2 g of latanoprost and mix evenly to obtain ophthalmic preparation 10.
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The invention belongs to the field of medicines, and relates to an ophthalmic pharmaceutical composition. The composition comprises 1 part by weight of an active pharmaceutical component and 0.02-200parts by weight of a liquid matrix, wherein the active pharmaceutical component is selected from at least one of anti-tumor drugs, anti-inflammatory drugs, immunosuppressive agents, angiogenesis inhibitors and glaucoma treatment drugs; and the liquid matrix is selected from at least one of methyl salicylate, ethyl salicylate, propyl salicylate, butyl salicylate, benzyl salicylate, phenethyl salicylate and phenylpropyl salicylate. The present invention also relates to an ophthalmic pharmaceutical box and a medicinal application of the ophthalmic pharmaceutical composition and the ophthalmic pharmaceutical box. The ophthalmic pharmaceutical composition can be injected into the eyes, slowly releases the active pharmaceutical component in the eyes for a long term, and can be degraded in the eyes.
Description
technical field [0001] The invention belongs to the field of medicine, and in particular relates to an ophthalmic pharmaceutical composition, an ophthalmic medicine box, and the medical application of the ophthalmic pharmaceutical composition and the ophthalmic medicine box. Background technique [0002] Anatomically, the eyeball includes two parts, the anterior segment of the eyeball and the posterior segment of the eyeball. Among them, the anterior segment of the eyeball accounts for about 1 / 3, which is composed of cornea, pupil, iris, aqueous humor, ciliary body and lens, and the posterior segment of the eyeball accounts for about 2 / 3. , consists of the vitreous, retina, macula, optic nerve, choroid, and sclera. Abnormalities in any part of the eyeball may cause eye diseases, among which, retinal phlebitis, diabetic retinopathy, proliferative vitreoretinopathy, choroidal neovascularization, age-related macular degeneration, cystoid macular edema, vitreomacular adhesion, m...
Claims
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IPC IPC(8): A61K9/00A61K47/14A61K45/00A61K31/337A61K31/436A61K31/4745A61K31/5575A61K31/573A61K31/58A61K39/395A61P3/10A61P7/10A61P9/14A61P25/00A61P27/02A61P27/06A61P35/00
CPCA61K9/0051A61K9/0019A61K47/14A61K45/00A61K31/58A61K31/436A61K31/573A61K31/5575A61K39/395A61K31/337A61K31/4745A61P27/02A61P27/06A61P3/10A61P9/14A61P7/10A61P25/00A61P35/00
Inventor 杨强刘继东
Owner SHENYANG XINGQI PHARM CO LTD
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