Composition containing moxidectin for treating parasites infestations

A technology of moxidectin and composition, applied in the field of treating and/or preventing parasitic infection of non-human mammals, can solve the problems of local tolerance, undisclosed, complicated preparation and use, etc.

Pending Publication Date: 2020-07-07
法国诗华大药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the treatment has two limitations: it can be used only once a month, and thus only has a one-month effectiveness, and it is an oral agent: degradation by the liver or gastric juices, delayed action, and drug interactions
It has many disadvantages: it is a suspension requiring complex preparation and use in general veterinary practice, and since it is an injectable product, it must be administered by a veterinary syringe, which can eventually cause local tolerability problems
[0022] Indeed, none of the prior art documents discloses a composition according to the invention comprising moxidectin or a salt thereof suitable for the treatment and / or prevention of endoparasites in non-human mammals (more precisely, canine heartworm) and ear mite infections (which are long-acting (at least 3 months) and easy to apply topically), and a single application is sufficient with optimized cytosolic concentration of the drug to minimize long-term toxicity problems in animals least

Method used

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  • Composition containing moxidectin for treating parasites infestations
  • Composition containing moxidectin for treating parasites infestations
  • Composition containing moxidectin for treating parasites infestations

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0183] Example 1: Formulation 1

[0184] In a manufacturing vessel, a moxidectin solution according to the composition depicted below has been prepared. With stirring a portion of benzyl alcohol, butylated hydroxytoluene (BHT), propylene carbonate and moxidectin have been added. Then, the volume was replenished with benzyl alcohol.

[0185]

example 2

[0186] Example 2: Formulation 2

[0187] In a manufacturing vessel, a moxidectin solution according to the composition depicted below has been prepared. With stirring a portion of isopropanol, BHT, dipropylene glycol monomethyl ether (DPGME) and moxidectin have been added. Then, make up the volume with isopropanol.

[0188]

example 3

[0189] Example 3: Formulation 3

[0190] The same method as Example 1 has been used.

[0191]

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Abstract

The present invention relates to a composition comprising moxidectin or a salt thereof for use in preventing and / or treating a parasite infestation in non-human mammals, in which said composition is topically administered every 3 to 9 months.

Description

technical field [0001] The present invention relates to a veterinary or pharmaceutical composition comprising moxidectin or a salt thereof for use in the prevention and / or treatment of parasitic infestation in non-human mammals, characterized in that each Topically administered from 3 to 9 months. [0002] It also relates to a method of treating and / or preventing parasitic infections in a non-human mammal comprising topically administering to said non-human mammal every 3 to 9 months a veterinary or Pharmaceutical composition. Background technique [0003] Non-human mammals, such as companion animals such as dogs, puppies, cats, kittens, rabbits, ferrets, horses, and pigs, are often susceptible to blood-feeding parasites and are therefore susceptible to infection. These parasites may be ectoparasites such as ticks, fleas, scabies, lice / nits, flies, mosquitoes or internal parasites. Furthermore, some of these parasites are intermediate hosts for endoparasites, such as fla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K9/00A61K47/10A61K47/22A61K47/32A61K9/08A61P33/14A61P33/00A61P33/10
CPCA61K9/0017A61K47/10A61K47/22A61K47/32A61K9/08A61K31/365A61P33/14A61P33/00A61P33/10A61K47/14A61K47/38
Inventor 弗洛伦斯·金伯托哈马迪·卡雷姆贝
Owner 法国诗华大药厂
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