Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition containing moxidectin for treating parasites infestations

A technology of moxidectin and composition, applied in the field of treating and/or preventing parasitic infection of non-human mammals, can solve the problems of local tolerance, undisclosed, complicated preparation and use, etc.

Pending Publication Date: 2020-07-07
法国诗华大药厂
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the treatment has two limitations: it can be used only once a month, and thus only has a one-month effectiveness, and it is an oral agent: degradation by the liver or gastric juices, delayed action, and drug interactions
It has many disadvantages: it is a suspension requiring complex preparation and use in general veterinary practice, and since it is an injectable product, it must be administered by a veterinary syringe, which can eventually cause local tolerability problems
[0022] Indeed, none of the prior art documents discloses a composition according to the invention comprising moxidectin or a salt thereof suitable for the treatment and / or prevention of endoparasites in non-human mammals (more precisely, canine heartworm) and ear mite infections (which are long-acting (at least 3 months) and easy to apply topically), and a single application is sufficient with optimized cytosolic concentration of the drug to minimize long-term toxicity problems in animals least

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition containing moxidectin for treating parasites infestations
  • Composition containing moxidectin for treating parasites infestations
  • Composition containing moxidectin for treating parasites infestations

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0183] Example 1: Formulation 1

[0184] In a manufacturing vessel, a moxidectin solution according to the composition depicted below has been prepared. With stirring a portion of benzyl alcohol, butylated hydroxytoluene (BHT), propylene carbonate and moxidectin have been added. Then, the volume was replenished with benzyl alcohol.

[0185]

example 2

[0186] Example 2: Formulation 2

[0187] In a manufacturing vessel, a moxidectin solution according to the composition depicted below has been prepared. With stirring a portion of isopropanol, BHT, dipropylene glycol monomethyl ether (DPGME) and moxidectin have been added. Then, make up the volume with isopropanol.

[0188]

example 3

[0189] Example 3: Formulation 3

[0190] The same method as Example 1 has been used.

[0191]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
viscosityaaaaaaaaaa
viscosityaaaaaaaaaa
Login to View More

Abstract

The present invention relates to a composition comprising moxidectin or a salt thereof for use in preventing and / or treating a parasite infestation in non-human mammals, in which said composition is topically administered every 3 to 9 months.

Description

technical field [0001] The present invention relates to a veterinary or pharmaceutical composition comprising moxidectin or a salt thereof for use in the prevention and / or treatment of parasitic infestation in non-human mammals, characterized in that each Topically administered from 3 to 9 months. [0002] It also relates to a method of treating and / or preventing parasitic infections in a non-human mammal comprising topically administering to said non-human mammal every 3 to 9 months a veterinary or Pharmaceutical composition. Background technique [0003] Non-human mammals, such as companion animals such as dogs, puppies, cats, kittens, rabbits, ferrets, horses, and pigs, are often susceptible to blood-feeding parasites and are therefore susceptible to infection. These parasites may be ectoparasites such as ticks, fleas, scabies, lice / nits, flies, mosquitoes or internal parasites. Furthermore, some of these parasites are intermediate hosts for endoparasites, such as fla...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K9/00A61K47/10A61K47/22A61K47/32A61K9/08A61P33/14A61P33/00A61P33/10
CPCA61K9/0017A61K47/10A61K47/22A61K47/32A61K9/08A61K31/365A61P33/14A61P33/00A61P33/10A61K47/14A61K47/38
Inventor 弗洛伦斯·金伯托哈马迪·卡雷姆贝
Owner 法国诗华大药厂
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com