The invention relates to an industrial secondary refrigerant. The industrial secondary refrigerant is composed of, by weight, 80 to 99% of glycol alkyl ether or propylene glycol alkyl ether compounds, 0.1 to 5% of a corrosion scale inhibitor and 0.9 to 10% function-adjusting liquid. According to the invention, the secondary refrigerant is added with the environment-friendly corrosion scale inhibitor which is harmless to the environment and human body, and the corrosion scale inhibitor can adsorb on metal surface and forms a physical adsorption protective film, so dissolved oxygen is blocked from diffusion to the metal surface; meanwhile, a compact passivation antirust film is generated through oxidation reduction reaction of the corrosion scale inhibitor with the metal surface, so metal oxidation is inhibited; moreover, the industrial secondary refrigerant provided by the invention also selects and uses the glycol alkyl ether or propylene glycol alkyl ether compounds with low viscosity, so effects of cold carrying and heat exchanging are guaranteed. The industrial secondary refrigerant in the invention is suitable for being used as the secondary refrigerant applied in industry under minus 80 to 200 DEG C, and an indirect heat transfer system in chemical industrial production and medicinal synthesis process. The secondary refrigerant is non-toxic and harmless, has excellent and safe heat transfer property and good fluidity at low temperature, does not precipitate and scale, and has the characteristics of environmental protection, cold carrying, heat transfer, corrosion inhibition, bacterial inhibition, low viscosity, corrosion resistance, etc.