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Eye drops containing fullerene and fullerene derivatives and preparation method of eye drops

A technology of derivatives and fullerenes, which is applied in the field of eye drops containing fullerenes and their derivatives and its preparation, can solve the problems of large side effects and excessive usage, and achieve high-efficiency treatment, suppression of eye inflammation, The effect of alleviating eye fatigue

Inactive Publication Date: 2020-07-17
上海紫河生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to solve the problems of excessive use of antibiotics and hormones in existing eye drops and large side effects of long-term use

Method used

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  • Eye drops containing fullerene and fullerene derivatives and preparation method of eye drops
  • Eye drops containing fullerene and fullerene derivatives and preparation method of eye drops
  • Eye drops containing fullerene and fullerene derivatives and preparation method of eye drops

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Refer to attached figure 1 , a kind of eye drop containing fullerene and its derivatives of the present embodiment is prepared by the following steps,

[0032] S100, ingredients, take fullererol (n=28), taurine, sodium hyaluronate and water for injection for later use, wherein the mass concentration of fullererol is 0.6%, the mass concentration of taurine is 0.2%, transparent The mass concentration of sodium hyaluronate is 0.2%, and the mass concentration of water for injection is 99%;

[0033] S200, mixing materials, mixing the fullerene and its derivatives prepared in step S100 with water for injection and stirring for 10 minutes, adding taurine and sodium hyaluronate and continuing to stir for 10 minutes to obtain initial eye drops;

[0034] S300, adding sodium chloride to adjust the osmotic pressure of the initial eye drops to 260-340mOsmol / kg to obtain mid-term eye drops;

[0035] S400, adjusting the pH, adding sodium hydroxide to adjust the pH of the medium-term...

Embodiment 2

[0037] Refer to attached figure 1 , a kind of eye drop containing fullerene and its derivatives of the present embodiment is prepared by the following steps,

[0038] S100, ingredients, take fullererol (n=28), taurine, sodium hyaluronate and water for injection for later use, wherein the mass concentration of fullererol is 1.0%, the mass concentration of taurine is 0.2%, transparent The mass concentration of sodium hyaluronate is 0.2%, and the mass concentration of water for injection is 98.6%;

[0039] S200, mixing materials, mixing the fullerene and its derivatives prepared in step S100 with water for injection and stirring for 10 minutes, adding taurine and sodium hyaluronate and continuing to stir for 10 minutes to obtain initial eye drops;

[0040] S300, adding sodium chloride to adjust the osmotic pressure of the initial eye drops to 260-340mOsmol / kg to obtain mid-term eye drops;

[0041] S400, adjusting the pH, adding sodium hydroxide to adjust the pH of the medium-te...

Embodiment 3

[0043] Refer to attached figure 1 , a kind of eye drop containing fullerene and its derivatives of the present embodiment is prepared by following steps:

[0044] S100, ingredients, take fullererol (n=28), taurine, sodium hyaluronate and water for injection for later use, wherein the mass concentration of fullererol is 3.0%, the mass concentration of taurine is 0.2%, transparent The mass concentration of sodium hyaluronate is 0.2%, and the mass concentration of water for injection is 96.6%;

[0045] S200, mixing materials, mixing the fullerene and its derivatives prepared in step S100 with water for injection and stirring for 10 minutes, adding taurine and sodium hyaluronate and continuing to stir for 10 minutes to obtain initial eye drops;

[0046] S300, adding sodium chloride to adjust the osmotic pressure of the initial eye drops to 260-340mOsmol / kg to obtain mid-term eye drops;

[0047] S400, adjusting the pH, adding sodium hydroxide to adjust the pH of the medium-term e...

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Abstract

The invention discloses eye drops containing fullerene and fullerene derivatives and a preparation method of the eye drops, and belongs to the technical field of eye drops. The eye drops comprise at least one of fullerene and fullerene derivatives, and the mass concentration of the fullerene and fullerene derivatives is 0.01%-10%. The eye drops further comprise taurine, sodium hyaluronate and water for injection, wherein the mass concentration of taurine is 0.1%-10%, the mass concentration of sodium hyaluronate is 0.01%-0.5%, and the mass concentration of water for injection is 90-99%. The fullerene and fullerene derivatives can be used for cell protection, sterilization and virus resistance, the taurine can be used for inhibiting eye inflammation, and the sodium hyaluronate can be used for relieving eye fatigue, so that the eye drops disclosed by the invention can be used for safely and efficiently treating eye inflammation diseases.

Description

technical field [0001] The invention belongs to the technical field of eye drops, in particular to an eye drop containing fullerene and derivatives thereof and a preparation method thereof. Background technique [0002] Due to the increasing environmental pollution, the widespread use of electronic products, the increased resistance of infectious microorganisms to antibiotics, and the increase in diseases that cause serious eye damage such as diabetes, the burden on the human eye has increased, and the disease of the eye organ has continued to increase. It has caused great trouble to people's life and work. [0003] For ocular disorders, topical medications offer many advantages over systemic medications. Subconjunctival and intravitreal injections can achieve effective drug concentrations in ocular tissues, but intraocular injections are a invasive method of administration, and repeated injections will greatly increase the incidence of infectious endophthalmitis Rate. Th...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/02A61K33/44A61K31/185A61K31/728A61P27/02A61P29/00
CPCA61K9/08A61K9/0048A61K47/02A61K33/44A61K31/185A61K31/728A61P27/02A61P29/00
Inventor 管书旺徐更
Owner 上海紫河生物科技有限公司
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