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Gel dressing for preventing and treating human papillomavirus infection and preparation method thereof

A human papillomavirus and gel technology, applied in the medical and health field, can solve the problems of inconvenient storage, limited use, low patient selectivity, etc.

Active Publication Date: 2020-07-17
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Human papillomavirus infection can be prevented and treated by vaccines, but the vaccines are too expensive, inconvenient to store, and have many restrictions on use
In addition, it can be prevented and treated by externally applied drugs. Currently, there are few drugs on the market, and the patient's options are low.

Method used

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  • Gel dressing for preventing and treating human papillomavirus infection and preparation method thereof
  • Gel dressing for preventing and treating human papillomavirus infection and preparation method thereof
  • Gel dressing for preventing and treating human papillomavirus infection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Taking the preparation of 1kg gel dressing as an example, the mass percentage of each raw material is: 0.1% of CP protein, 0.1% of carbomer, 0.1% of carboxylated chitosan, 15% of glycerin, 0.5% of gum arabic, and water as the balance. The sum of the mass percentages of raw materials is 100%.

[0027] The gel dressing is prepared by the following method: add carbomer to an appropriate amount of purified water, heat to 80°C, stir for half an hour, and place it at room temperature overnight to make it fully swell; add an appropriate amount of purified water to dissolve the CP protein; add gum arabic Appropriate amount of purified water, mix well, 80 ℃ water bath for half an hour; dissolve carboxylated chitosan in appropriate amount of purified water, mix with carbomer aqueous solution to obtain glue; add gum arabic aqueous solution, glycerin to the glue in turn, mix well ; Slowly add the CP protein solution to the mucilage, add water to the full amount, mix well, and you h...

Embodiment 2

[0029] Taking the preparation of 1kg gel dressing as an example, the mass percentage of each raw material is: 0.05% CP protein, 0.3% carbomer, 0.3% carboxylated chitosan, 10% glycerin, 1% gum arabic, and water as the balance.

[0030] The gel dressing is prepared by the following method: add carbomer to an appropriate amount of purified water, heat to 70°C, stir for 20 minutes, and place it at room temperature overnight to fully swell it for use; add an appropriate amount of purified water to dissolve the CP protein, Stand-by; add appropriate amount of purified water to gum arabic, mix well, bathe in 70°C water for 20 minutes, and stand-by; dissolve carboxylated chitosan in proper amount of purified water, mix with carbomer aqueous solution to obtain glue; Add aqueous solution of gum arabic and glycerin, and mix well; slowly add CP protein solution to the mucilage, add water to the full amount, mix well, and the product is ready.

Embodiment 3

[0032] Taking the preparation of 1 kg of gel auxiliary materials as an example, the mass percentages of each raw material are: CP protein 0.01%, carbomer 1%, carboxylated chitosan 1%, glycerin 5%, gum arabic 3%, and water as the balance.

[0033] The gel dressing is prepared by the following method: add carbomer to an appropriate amount of purified water, heat to 80°C, stir for 40 minutes, and leave it at room temperature overnight to make it fully swell; add an appropriate amount of purified water to dissolve the CP protein; add gum arabic Appropriate amount of purified water, mix evenly, and bathe in 80°C water for 40 minutes; dissolve carboxylated chitosan in appropriate amount of purified water, mix with carbomer aqueous solution to obtain mucilage; add gum arabic aqueous solution and glycerin to the mucilage in turn, mix ; Slowly add the CP protein solution to the mucilage, add water to the full amount, mix well, and you have it.

[0034] Investigation of CP protein gel r...

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Abstract

The invention discloses a gel dressing for preventing and treating human papillomavirus infection. The gel dressing is prepared by taking a CP protein, carbomer, carboxylated chitosan, glycerol and Arabic gum as main raw materials, wherein the mass percentages of the raw materials are as follows: 0.01-0.1% of the CP protein, 0.1-1% of the carbomer, 0.1-1% of the carboxylated chitosan, 5-15% of theglycerol, 0.5-3% of the Arabic gum and the balance of water. According to the invention, the CP protein is used as a main effective component, and the whole CP protein is negatively charged, can be combined with HPV viruses to inactivate the HPV viruses, and has repair capability on damaged tissues. The invention also discloses an application of the gel dressing in preparing medicaments for preventing and treating human papillomavirus infection.

Description

technical field [0001] The invention belongs to the field of medicine and hygiene, and in particular relates to a gel dressing for preventing and treating human papillomavirus (HPV) infection and a preparation method. Background technique [0002] In the 1980s, German virologist Harald Zur Hausen first proposed that HPV infection is closely related to cervical cancer. In 1995, the special meeting of IRAC (International Organization for Research on Cancer) confirmed that HPV infection is a necessary condition for cervical cancer. 99.7% HPV can be detected in cervical cancer tissue, and cervical cancer will hardly occur in those who are not infected with HPV (negative predictive value >99%). Due to the discovery of the cause of cervical cancer, Hausen became one of the winners of the 2008 Nobel Prize in Medicine. [0003] High-risk HPV is a protein-coated virus with the smallest double-stranded DNA. There are currently more than 100 types of HPV. It is a mucous membrane an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K9/06A61K47/32A61K47/36A61P31/20A61P35/00A61K31/78
CPCA61K38/1767A61K31/78A61K9/06A61K9/0014A61K47/32A61K47/36A61P31/20A61P35/00A61K2300/00
Inventor 段小群王宇晖宋恒智卢曦徐笑天林世源蒋志敏
Owner GUILIN MEDICAL UNIVERSITY
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