Application method and system of biomarker in evaluation of ovarian cancer

A biomarker and ovarian cancer technology, applied in the field of ovarian cancer assessment, can solve the problems of low sensitivity and specificity of early detection and early warning of ovarian cancer malignant tumors, imperfect evaluation of ovarian cancer treatment effect, etc., to achieve simplified measurement, The effect of improving accuracy

Pending Publication Date: 2020-07-17
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The technical problem to be solved by the present invention is that the sensitivity and specificity of the existing biomarkers in the prior art in the evaluation of ovarian cancer and the early detection and early warning of ovarian cancer malignant tumors are not strong; at the same time, the evaluation of ovarian cancer treatment effect is not strong Perfect defects, providing a biomarker-based ovarian cancer assessment method and system that can monitor changes in ovarian cancer well and improve assessment accuracy

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  • Application method and system of biomarker in evaluation of ovarian cancer
  • Application method and system of biomarker in evaluation of ovarian cancer
  • Application method and system of biomarker in evaluation of ovarian cancer

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Embodiment 1

[0147] 1. Experimental materials

[0148] Serum samples from patients with ovarian cancer were collected from patients undergoing ovarian cancer surgery at Renmin Hospital of Wuhan University during preoperative examinations. All patients had not received radiation therapy, chemotherapy and antineoplastic drugs before operation, and all had complete clinical and pathological data. 95 patients with ovarian cancer (ovarian cancer group), aged 34-66 years, with an average age of 53.3 years. Serum samples of 40 healthy volunteers (normal control group), aged 30-65 years, with an average age of 54.5 years. There was no significant difference in age composition between the ovarian cancer group and the normal control group.

[0149] 2. Experimental method

[0150] (1) Acquire the CA-125 data, HE4 data and PA data of the serum sample to be tested.

[0151] (2) Determine the area under the receiver operating characteristic curve according to the CA-125 data, the HE4 data and the PA...

Embodiment 2

[0164] The application method of the biomarkers provided in the embodiments of the present invention in the evaluation of ovarian cancer is as follows: figure 1 As shown, as a preferred embodiment, such as Figure 10 As shown, the method for measuring the concentration of ovarian cancer biomarkers in ovarian cancer tumors by medical measuring equipment provided by the embodiments of the present invention includes:

[0165] S201. Determine the concentration of at least one small molecule biomarker from a sample from the subject; wherein, when compared with a control sample, an increase or decrease in the concentration of the sample indicates that the subject is suffering from ovarian cancer, or have an increased risk of developing ovarian cancer.

[0166] S202. Compared with the control, the at least one small molecule biomarker whose concentration is increased is selected from the group consisting of dihydroxybutyric acid and trihydroxybutyric acid.

[0167] S203. Compared w...

Embodiment 3

[0176] The application method of the biomarkers provided in the embodiments of the present invention in the evaluation of ovarian cancer is as follows: figure 1 As shown, as a preferred embodiment, such as Figure 11 As shown, the method for identifying benign and malignant ovarian cancer by using the identification program provided by the ovarian cancer identification device provided in the embodiment of the present invention includes:

[0177] S301. Acquire CA-125 data, HE4 data and PA data of the serum sample to be tested.

[0178] S302. Determine an area value under a receiver operating characteristic curve according to the CA-125 data, the HE4 data, and the PA data.

[0179] S303. Determine whether the ovarian mass corresponding to the serum sample to be detected is good or bad according to the area value.

[0180] The determination of the area value under the receiver operating characteristic curve according to the CA-125 data, the HE4 data and the PA data provided in ...

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Abstract

The invention discloses an ovarian cancer evaluation method based on biomarkers, which includes the following steps: collecting three-dimensional ovarian image of a subject by a medical image device,and performing image denoising enhancement treatment; according to the enhanced image, determining the position of the ovarian tumor, and testing the concentration of at least one micromocular biomarker in the ovarian tumor in the subject by using a medical measurement device, and comparing the acquired concentration of the micromocular biomarker with a reference sample; if the concentration of the micromocular biomarker exceeds or is lower than the corresponding threshold value, acquiring CA 125 data, HE4 data and PA data of a to-be-detected serum sample of the subject by using an identification program, and according to the CA 125 data, HE4 data and PA data, calculating the area value of a working characteristic curve, and according to the biomarker level and the area value of the working characteristic curve, evaluating the condition of the ovarian tumor of the subject by using the evaluation program, and generating an evaluation report so that a doctor can make a diagnosis and select therapy methods.

Description

technical field [0001] The invention belongs to the technical field of ovarian cancer assessment, and in particular relates to a method and system for applying biomarkers in ovarian cancer assessment. Background technique [0002] Ovarian cancer is one of the common malignant tumors of female reproductive organs, and its incidence rate is second only to cervical cancer and uterine body cancer. Epithelial carcinoma is the most common ovarian malignancy, followed by malignant germ cell tumors. Among them, the death rate of ovarian epithelial cancer accounts for the first place among all kinds of gynecological tumors, which poses a serious threat to women's lives. Because the ovary is located deep in the pelvic cavity, the body surface is not easy to touch, and it lacks typical symptoms, so it is difficult to detect early. [0003] At present, the common benign and malignant risk assessment of ovarian masses in hospitals is to detect common tumor markers, which have low sensi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30G16H50/50G16H15/00G06T7/00G06T5/00G01N33/574
CPCG16H50/30G16H50/50G16H15/00G06T7/0012G06T5/002G01N33/57449G01N33/57488G06T2207/10081G06T2207/10088G06T2207/10116G06T2207/10132G06T2207/30096
Inventor 吴德斌刘晨李秉枢洪莉郭雯君李新
Owner WUHAN UNIV
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