Modification method of temperature-sensitive hydrogel material, modified temperature-sensitive hydrogel material and biological 3D printing ink

A temperature-sensitive hydrogel, hydrogel technology, applied in the direction of additive processing, can solve the problems of extrusion swelling, poor mechanical strength of hydrogel, structural collapse, etc., and achieve the effect of improving mechanical strength

Active Publication Date: 2020-08-04
HANGZHOU MEDZONE BIO-TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such hydrogels often have poor mechanical strength, which leads to extrusion swelling and even structural collapse during printing.

Method used

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  • Modification method of temperature-sensitive hydrogel material, modified temperature-sensitive hydrogel material and biological 3D printing ink
  • Modification method of temperature-sensitive hydrogel material, modified temperature-sensitive hydrogel material and biological 3D printing ink
  • Modification method of temperature-sensitive hydrogel material, modified temperature-sensitive hydrogel material and biological 3D printing ink

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Experimental program
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preparation example Construction

[0070] The preparation method of polycaprolactone-polyethylene glycol-polycaprolactone is as follows:

[0071] Mix polyethylene glycol and ε-caprolactone in the presence of a catalyst and react at 130-150°C for 6-10 hours. The reaction formula is as follows:

[0072]

[0073] After the reaction is completed, it is quenched below -20°C and terminated with CH 2 Cl 2 Ultrasonic dissolution, the dissolved CH 2 Cl 2 The solution was added dropwise to glacial ether for settling, and the white product gradually precipitated out. The mixture was suction-filtered and washed at least twice with anhydrous ether, and the resulting product was vacuum-dried to obtain a white solid powder.

[0074] Optionally, the catalyst includes stannous isooctanoate.

[0075] Optionally, the polyethylene glycol has a molecular weight of 4000-10000 Da.

[0076] Optionally, the molar ratio of polyethylene glycol to ε-caprolactone is 1: (35-50).

[0077] Optionally, the reaction environment is an ...

Embodiment 1

[0089] The embodiment of the present application provides a method for modifying a temperature-sensitive hydrogel material, and a modified temperature-sensitive hydrogel material, which includes the following steps:

[0090] Take 2g of polyethylene glycol (Mn=4000Da, 0.5mmol) whose terminals are all hydroxyl groups, and 2.28g (2.2mL, 20mmol) ε-caprolactone into a 25mL round-bottomed flask, and then dropwise add 3‰ of Sn(Oct ) 2 and melted at 60°C, after deoxygenation by pumping Ar gas for three times, reacted at 140°C for 8h, and quenched at -20°C after the reaction was completed, and used 5mL of CH 2 Cl 2 Ultrasonic dissolution, the dissolved CH 2 Cl 2 The solution was added dropwise to 200 mL of glacial ether for sedimentation, and the white product was gradually precipitated. The mixture was suction-filtered with a sand core funnel and washed 3 times with anhydrous ether, and the resulting product was vacuum-dried to obtain a white solid powder PC 1 , the copolymer is ...

Embodiment 2

[0092] The embodiment of the present application provides a method for modifying a temperature-sensitive hydrogel material, and a modified temperature-sensitive hydrogel material, which includes the following steps:

[0093] Take 3g of polyethylene glycol (Mn=6000Da, 0.5mmol) and 2.28g (2.2mL, 20mmol) of ε-caprolactone, both of which are hydroxyl groups, and add them to a 25mL round-bottomed flask, and then add 3‰ of Sn(Oct ) 2 and melted at 60°C, after deoxygenation by pumping Ar gas for three times, reacted at 140°C for 8h, and quenched at -20°C after the reaction was completed, and used 5mL of CH 2 Cl 2 Ultrasonic dissolution, the dissolved CH 2 Cl 2 The solution was added dropwise to 200 mL of glacial ether for sedimentation, and the white product was gradually precipitated. The mixture was suction-filtered with a sand core funnel and washed 3 times with anhydrous ether, and the resulting product was vacuum-dried to obtain a white solid powder PC 2 , the copolymer is ...

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Abstract

The invention discloses a modification method of a temperature-sensitive hydrogel material, the modified temperature-sensitive hydrogel material and biological 3D printing ink, and belongs to the technical field of hydrogel. The method for modifying the temperature-sensitive hydrogel material includes partially crystallizing a cross-linked network of the temperature-sensitive hydrogel material. The crystal is a highly ordered and stable object, and a cross-linked network part of the temperature-sensitive hydrogel material is crystallized to stabilize the cross-linked network structure of the hydrogel, so that the hydrogel can be recovered under the action of shear force. The cross-linked network is partially crystallized, so that the cross-linked network of the temperature-sensitive hydrogel material has a crystallization area, and compared with an amorphous cross-linked network, the crystallization area can significantly improve the stability of the cross-linked network and the mechanical strength of the hydrogel, and the hydrogel still maintains the properties of shear thinning and rapid curing.

Description

technical field [0001] The present application relates to the field of hydrogel technology, in particular, to a method for modifying a temperature-sensitive hydrogel material, a modified temperature-sensitive hydrogel material and bio-3D printing ink. Background technique [0002] Bio-3D printing technology is a high-resolution and high-precision rapid prototyping technology, which has attracted extensive attention as an emerging research direction. Bio-3D printing technology is diverse, among which micro-extrusion is a powerful method, the bio-ink in the barrel is extruded through the nozzle under pressure and stacked layer by layer on the platform. Therefore, there is a need for bioinks that can not only be extruded smoothly but also can be quickly set after deposition. That is to say, as a printable biomaterial, it needs to have both shear thinning and fast curing properties. Hydrogels, especially temperature-responsive hydrogels, are ideal printable materials for micro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L67/04C08G63/664C08G63/85B33Y70/00
CPCC08J3/075C08G63/664C08G63/823B33Y70/00C08J2367/04
Inventor 王利群崔悦诚周洋陈捷
Owner HANGZHOU MEDZONE BIO-TECH CO LTD
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