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Drug delivery balloon catheter

A balloon catheter and balloon technology, applied in the field of drug-eluting balloons, can solve the problems of uncontrollable, unpredictable, insufficient drug amount, etc.

Active Publication Date: 2020-08-04
VASCUROS MEDICAL SHANGHAI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] (2) There are insufficient, uncontrollable and unpredictable problems in the drug release, transfer and absorption process
But it also increases the cost and time required to perform the procedure
[0016] (4) In addition, before the drug reaches the treated lesion, a large amount of uncontrollable drug loss may cause drug-coated particles or even drug fragments
And a large number of drug-coated particles or debris may break off the balloon surface and enter the patient's bloodstream

Method used

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  • Drug delivery balloon catheter
  • Drug delivery balloon catheter
  • Drug delivery balloon catheter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0264] Transport loss / travel loss

[0265] Use the same drug coating formula and coating method to coat the test object.

[0266] Test object

[0267] Device A employs a Figure 6b Similar drug delivery systems, the distal end of the outer cannula is as follows Figure 11b The external expansion shown.

[0268] The drug delivery device of device B is a common balloon catheter (DEB) without an outer sheath.

[0269] experimental method

[0270] The in vitro test method was adapted from Seidlitz et al. In Vitro Assay of Drug Transfer from Drug-Coated Balloons (2013), PLoS ONE8(12):e83992 (doi:10.1371 / journal.pone.0083992).

[0271] The following adjustments were made:

[0272] ·Silicone tube is used to simulate the blood vessel wall.

[0273] • The simulated vessel wall was not imaged, therefore the balloon was not fluorescently treated.

[0274] • The drug components were extracted from acetonitrile and analyzed at 227nm using a UV spectrometer.

[0275] • The balloon ...

experiment example 2

[0281] sheath loss

[0282] Use the same drug coating formula and coating method to coat the test object.

[0283] Test object

[0284] Device C employs a Figure 6b Similar drug delivery systems, the distal end of the outer cannula is as follows Figure 11a straight as shown.

[0285] Device D employs a Figure 6b Similar drug delivery systems, the distal end of the outer cannula is as follows Figure 11b The external expansion shown.

[0286] experimental method

[0287] The in vitro test method was adapted from Seidlitz et al. In Vitro Assay of Drug Transfer from Drug-Coated Balloons (2013), PLoS ONE8(12):e83992 (doi:10.1371 / journal.pone.0083992).

[0288] The following changes were made:

[0289] ·Silicone tube is used to simulate the blood vessel wall.

[0290] • The simulated vessel wall was not imaged, therefore the balloon was not fluorescently treated.

[0291] • The drug components were extracted from acetonitrile and analyzed at 227nm using a UV spectromet...

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PUM

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Abstract

The current invention relates to the provision of drug eluting balloons and balloon catheters, where the drug coating is protected by a sheath.

Description

technical field [0001] The present invention relates to various drug-eluting balloons that can be inserted into human body lumens and can deposit drug components on treatment sites. [0002] technical background [0003] The listing or discussion of a published document in this specification should not be taken as an acknowledgment that said document is part of the state of the art or is common general knowledge. [0004] Coronary artery disease / peripheral artery disease is a common blood circulation disorder in which plaque builds up in the arteries that restrict blood flow to various parts of the body. The current typical treatment methods are: coronary artery bypass grafting, stent implantation and balloon angioplasty. Months after stenting and balloon angioplasty, some patients develop a narrowing of the vessel wall at the intervention site, called restenosis. The recognition of the problems associated with stenosis and restenosis has led to the development of drug elut...

Claims

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Application Information

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IPC IPC(8): A61M25/10A61M25/01A61L29/08A61L29/16
CPCA61M25/104A61M25/01A61M25/0069A61M25/09A61M25/10A61M2025/105A61M2025/1081A61M2025/0186A61M2025/0039A61M25/0108A61M25/005A61M2025/0062A61M25/0172A61L29/08A61L29/16A61M2025/1063A61M2025/09166A61M2025/0183A61M2025/0047A61L2300/232A61L2300/416A61M25/0097A61M25/0105
Inventor 骆静南王红蕾李博懐
Owner VASCUROS MEDICAL SHANGHAI CO LTD
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