Preparation method and application of photo-thermal-magnetic composite material based on hollow carbon spheres

Abstract

The invention discloses a photo-thermal-magnetic composite material based on hollow carbon spheres. The hollow carbon shell coated nano-particle is based on a hollow carbon shell coated hollow nano-particle UCNPs / Fe3O4@h-C, specifically, NaY / GdF4: Yb stabilized by oleic acid, NaYF4 (UCNPs) and superparamagnetic Fe3O4 are used as inner cores, under the interaction of weak acid and weak base, UCNPsand Fe3O4 nanoparticles are introduced into a hollow carbon sphere to prepare the hollow carbon coated UCNPs and Fe3O4 synthesized core-shell structure nanoparticles. The invention also discloses a preparation method of the photo-thermal-magnetic composite material based on the hollow carbon spheres, and the preparation method comprises the following steps: (1) respectively synthesizing oleic acid-stabilized Fe3O4 nanoparticles and NaY / GdF4: Yb, Er@NaYF4 (UCNPs) nanocrystals with core-shell structures, and (2) synthesizing the multifunctional nano material UCNPs / Fe3O4@h-C. The invention also discloses a contrast agent used for simultaneously realizing medical magnetic resonance imaging (MRI) and enhanced upconversion luminescence (UCL) imaging, and an application of the contrast agent usedas a material for preparing near-infrared photothermal therapy and photothermal imaging reagents.

Description

technical field [0001] The invention relates to the technical field of medical bionano materials, in particular to a hollow carbon sphere-based optical, thermal and magnetic composite material, a preparation method and its application in the medical field. Background technique [0002] Because of its unique properties, nanomaterials have attracted more and more attention from the scientific community and countries all over the world. In the field of cancer treatment, the characteristics of nanomaterials also provide new research directions for cancer treatment and diagnosis. Due to the structure of the tumor microenvironment and the particularity of the size of nanomaterials, nanomaterials have high permeability and retention in tumor sites, and are highly enriched in tumor sites but rarely exist in normal tissues, reducing the impact of nanomaterials on the body. toxic side effects. Nanoparticles loaded with cancer therapeutic drugs gather at the tumor site, which also im...

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Problems solved by technology

[0007] In the prior art, the combination of UCNPs and magnetic substances is mainly divided into three methods, one method is dense SiO 2 (or mSiO 2 ) coated with magnetic substances or UCNPs, and UCNPs or magnetic substances are bound to the silicon surface; the second is to modify UCNPs and magnetic substances with different ligands, and the chemical reaction between the ligands is used to combine the two; the third is to combine UCNPs and magnetic The substances are co-coated in the silicon layer, but the nanoparticles prepared by these methods are easy to agglomerate and have irregular shapes, and it is difficult to construct multifunctional nanocrystals with good stability and uniform shape, which limits their application.

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