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A rare earth-hyaluronic acid coordination polymer-coated vs 2 Nanostructures and their preparation methods and applications

A technology of coordination polymers and hyaluronic acid, which is applied in pharmaceutical formulations, chemical instruments and methods, medical preparations of non-active ingredients, etc., can solve problems such as poor biocompatibility and low photothermal conversion efficiency of photothermal materials , to achieve the effect of uniform size, good down-conversion luminescence performance, and good dispersion

Active Publication Date: 2022-04-05
JIANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the potential clinical application of photothermal therapy faces challenges such as low photothermal conversion efficiency and poor biocompatibility of photothermal materials.

Method used

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  • A rare earth-hyaluronic acid coordination polymer-coated vs <sub>2</sub> Nanostructures and their preparation methods and applications
  • A rare earth-hyaluronic acid coordination polymer-coated vs <sub>2</sub> Nanostructures and their preparation methods and applications
  • A rare earth-hyaluronic acid coordination polymer-coated vs <sub>2</sub> Nanostructures and their preparation methods and applications

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] VS coated with a rare earth-hyaluronic acid coordination polymer of this embodiment 2 The preparation method of nanostructure, the steps are as follows:

[0033] (1) Add 0.5mmol sodium hyaluronate to 10mL water and swell for 2 hours; weigh 1,2-hexacanoyl-sn-glyceryl-3-phosphocholine (0.008mmol) at a molar ratio of 1:1 , cholesterol (0.008mmol) and VS 2 Nanoparticles (0.5mmol), and dissolve it in chloroform solution to obtain a mixed solution;

[0034] (2) Then add the mixed solution of step (1) into the swollen sodium hyaluronate solution, take Gd(NO 3 ) 3 Aqueous solution (1mL, 0.04mol / L) and Eu(NO 3 ) 3 The aqueous solution (1mL, 0.32mol / L) was mixed with the above solution, magnetically stirred at room temperature for 5 minutes, and transferred to a three-necked flask for 24 hours under magnetic stirring at room temperature under the condition of nitrogen protection; after the reaction was complete, the product was dissolved in distilled water Freeze-drying aft...

Embodiment 2

[0037] VS coated with a rare earth-hyaluronic acid coordination polymer of this embodiment 2 The preparation method of nanostructure, the steps are as follows:

[0038] (1) Add 0.5mmol sodium hyaluronate to 10mL water and swell for 2 hours; weigh 1,2-hexacanoyl-sn-glyceryl-3-phosphocholine (0.008mmol) at a molar ratio of 1:1 , cholesterol (0.008mmol) and VS 2 Nanoparticles (0.4mmol), and dissolve it in chloroform solution to obtain a mixed solution;

[0039] (2) Then add the mixed solution of step (1) into the swollen sodium hyaluronate solution, take Gd(NO 3 ) 3 Aqueous solution (1mL, 0.02mol / L) and Eu(NO 3 ) 3 Aqueous solution (1mL, 0.16mol / L) was mixed with the above solution, stirred magnetically at room temperature for 5 minutes, and transferred to a three-necked flask to react with magnetic stirring for 24 hours at room temperature under nitrogen protection; after the reaction was complete, the product was dissolved in distilled water Freeze-drying after 20 hours o...

Embodiment 3

[0041] VS coated with a rare earth-hyaluronic acid coordination polymer of this embodiment 2 The preparation method of nanostructure, the steps are as follows:

[0042] (1) Add 0.5mmol sodium hyaluronate to 10mL water and swell for 2 hours; weigh 1,2-hexacanoyl-sn-glyceryl-3-phosphocholine (0.008mmol) at a molar ratio of 1:1 , cholesterol (0.008mmol) and VS 2 Nanoparticles (0.45mmol), and dissolve it in chloroform solution to obtain a mixed solution;

[0043] (2) Then add the mixed solution of step (1) into the swollen sodium hyaluronate solution, take Gd(NO 3 ) 3 Aqueous solution (1mL, 0.04mol / L) and Eu(NO 3 ) 3 Aqueous solution (1mL, 0.48mol / L) was mixed with the above solution, stirred magnetically for 5 minutes at room temperature, and transferred to a three-necked flask to react with magnetic stirring for 24 hours under the condition of nitrogen protection at room temperature; after the reaction was complete, the product was dissolved in distilled water Freeze-dryin...

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Abstract

The invention belongs to the field of rare earth down-conversion nanomaterials, and relates to a rare earth-hyaluronic acid coordination polymer-coated VS 2 Nanostructures and their fabrication methods and applications. The rare earth-hyaluronic acid coordination polymer (EuCP) with down-conversion luminescence properties was coated on vanadium disulfide nanoparticles (VS 2 NPs) surface, the preparation of rare earth-hyaluronic acid coordination polymer-coated VS 2 Nano-structure. VS coated with rare earth-hyaluronic acid coordination polymer prepared by the present invention 2 Nano-nanoparticles have uniform chemical composition, high purity, and uniform shape, and exhibit excellent photothermal performance as a photothermal conductive agent. In addition, this method overcomes the single-function disadvantage of hyaluronic acid as a traditional targeted drug, does not require large-scale equipment and harsh reaction conditions, is environmentally friendly, and has a high yield. It provides a new idea in the direction of fluorescence imaging to guide photothermal therapy.

Description

technical field [0001] The invention belongs to the field of rare earth down-conversion nanomaterials, and relates to a rare earth-hyaluronic acid coordination polymer-coated VS2 nanostructure and its preparation method and application. Background technique [0002] Photothermal therapy is a treatment method that uses photothermal materials to convert light energy into localized superheating, thereby killing cancer cells. The photothermal conduction agent is injected into the human body, and the targeted photothermal conduction agent will be absorbed by tumor cells, and then a certain wavelength of laser light is used to excite the photothermal conduction agent retained in the tumor tissue to obtain energy from the light, and then the light It can be converted into heat energy, thereby increasing the temperature of the environment around the tumor and triggering the death of cancer cells. Because of its non-invasiveness, precise controllability and good therapeutic effect, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/02C09K11/06A61K41/00A61K47/61A61P35/00
CPCC09K11/025C09K11/06A61K41/0052A61K47/61A61P35/00C09K2211/182
Inventor 钟声亮夏发明黎泓波
Owner JIANGXI NORMAL UNIV
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