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Polyvinyl alcohol hydrogel with asymmetric pore diameters

A polyvinyl alcohol and hydrogel technology, applied in medical science, bandages, etc., can solve the problems of difficult control of preparation conditions, limitation of clinical application, and inability to realize large-scale preparation, and achieve the goal of promoting wound healing and excellent biocompatibility Effect

Active Publication Date: 2020-08-07
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the major disadvantage of the bilayer hydrogel is that the interface between the two layers is weak, and it is easy to separate and fall off during use, which limits its clinical application.
In addition, researchers have also tried to prepare hydrogels with heterogeneous structures by chemical hydrothermal synthesis, electrospinning and other technologies, but the preparation conditions are complex and difficult to control, and large-scale preparation cannot be achieved, and the residue of toxic chemical cross-linking agents does not meet the requirements of clinical applications. Require
Moreover, the pore size changes of the heterogeneous structure hydrogels in the prior art are all stepped, rather than gradual

Method used

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  • Polyvinyl alcohol hydrogel with asymmetric pore diameters
  • Polyvinyl alcohol hydrogel with asymmetric pore diameters
  • Polyvinyl alcohol hydrogel with asymmetric pore diameters

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Step 1: dissolving sodium carboxymethyl cellulose and polyvinyl alcohol in deionized water at a content of 2.4% and 28% respectively to obtain a uniform clear solution;

[0045] Step 2: Dissolve polyethylene glycol powder with a content of 7.5% at 80°C into the 1:1 mixed solution in Step 1, and dissolve until clear;

[0046] Step 3: Put the mixture prepared in Step 2 at room temperature for 50 minutes, then pour it into the template, put it in a -20°C refrigerator to freeze and cross-link, freeze it for 6 hours, take it out of the refrigerator to get the hydrogel, and cycle freeze for 4 Second-rate.

[0047] In step one, the molecular weight of polyvinyl alcohol is 95000, and the viscosity of sodium carboxymethylcellulose is 8000cP. In step 2, the molecular weight of polyethylene glycol is 1500.

Embodiment 2

[0049] Step 1: dissolving sodium carboxymethylcellulose and polyvinyl alcohol in deionized water at a content of 3.2% and 18% respectively to obtain a uniform clear solution;

[0050]Step 2: Dissolve polyethylene glycol powder with a content of 7.0% at 85°C into the 1:1 mixed solution in Step 1, and dissolve it until clear;

[0051] Step 3: Put the mixture prepared in Step 2 at room temperature for 80 minutes, then pour it into the template, put it in a -22°C refrigerator to freeze and cross-link, take it out of the refrigerator after freezing for 14 hours, and then get the hydrogel, cycle freezing for 1 Second-rate.

[0052] In step one, the molecular weight of polyvinyl alcohol is 80000, and the viscosity of sodium carboxymethylcellulose is 5500cP. In step 2, the molecular weight of polyethylene glycol is 4000.

Embodiment 3

[0054] Step 1: dissolving sodium carboxymethyl cellulose and polyvinyl alcohol in deionized water at a content of 1.4% and 19% respectively to obtain a uniform clear solution;

[0055] Step 2: Dissolve polyethylene glycol powder with 10% content at 90°C into the 2:1 mixed solution in Step 1, and dissolve until clear;

[0056] Step 3: Put the mixture prepared in Step 2 at room temperature for 10 minutes, then pour it into the template, put it in a -18°C refrigerator to freeze and cross-link, freeze for 20 hours and then take it out of the refrigerator to get a hydrogel, and cycle freeze for 2 Second-rate.

[0057] In step one, the molecular weight of polyvinyl alcohol is 100,000, and the viscosity of sodium carboxymethyl cellulose is 9300cP. In step 2, the molecular weight of polyethylene glycol is 3000.

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Abstract

The invention relates to polyvinyl alcohol hydrogel with asymmetric pore diameters. The aperture of the upper surface of the polyvinyl alcohol hydrogel is 5-20 [mu] m, the aperture of the lower surface of the polyvinyl alcohol hydrogel is 80-150 [mu] m, and the aperture of the polyvinyl alcohol hydrogel is gradually increased from the upper surface to the lower surface. The polyvinyl alcohol hydrogel has excellent biocompatibility and has the functions of resisting bacteria, preventing adhesion, absorbing seepage, promoting wound healing, observing the wound healing process in situ and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a spongy hydrogel dressing with asymmetric apertures and a preparation method thereof. Background technique [0002] Hydrogel is a water-insoluble soft material with water retention. This material is soft, can maintain a certain shape, and absorb a large amount of water. [0003] The good water absorption of hydrogel makes it potential in the application of wound dressings. However, the hydrogel dressings currently used clinically can only be used as moisturizing and isolation protection materials, which cannot meet the requirements of absorbing exudate and protecting the skin as wound dressings. Clinical requirement to prevent external bacteria from infiltrating the wound. [0004] From the perspective of the structure of the hydrogel material, there is a contradiction between realizing the function of absorbing seepage and realizing the function of preventing ba...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08J3/075C08L29/04C08L71/02
CPCA61L26/0052A61L26/008A61L26/0085C08J3/075C08J2329/04C08J2471/02C08L29/04C08L71/02
Inventor 范代娣李阳朱晨辉杨婵媛贾利平马晓轩严建亚
Owner NORTHWEST UNIV
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