Method for simultaneously determining contents of four effective components in tripterygium wilfordii

Abstract

The invention discloses a method for simultaneously determining the contents of four effective components in tripterygium wilfordii. The contents of triptolide, triptonide, tripterine and wilforlide in tripterygium wilfordii are measured. The method is accurate, high in sensitivity, good in repeatability and reliable in result, a basis is provided for quality control and evaluation of the tripterygium wilfordii medicinal material, and a foundation is laid for determination of the optimal production place of the medicinal material. The content difference of the four effective components in thetripterygium wilfordii medicinal materials from different producing areas is studied. The method is helpful for determining a suitable producing area of medicinal materials in production and guiding medicinal material harvesting.

Description

technical field [0001] The invention relates to a method for simultaneously measuring the contents of four active ingredients in Tripterygium wilfordii, belonging to the field of pharmaceutical technology. Background technique [0002] The medicinal material Tripterygium wilfordii is the root of the Euonymus family Tripterygium genus. It is mainly produced in Zhejiang, Hunan, Jiangxi, Anhui, Guizhou and other places. It has various pharmacological effects such as anti-inflammatory, antibacterial, and immune regulation. It is used to treat rheumatoid arthritis. Inflammation, systemic lupus erythematosus, etc., widely used clinically. The main active components of Tripterygium wilfordii are diterpene lactones, alkaloids and triterpenoids, but the main active components are also toxic components, and adverse reactions have been reported from time to time. At present, the evaluation of Tripterygium wilfordii mainly focuses on the content determination of the main active ingredi...

AI Technical Summary

Problems solved by technology

The main active ingredients of Tripterygium wilfordii are diterpene lactones, alkaloids and triterpenoids, but the main active ingredients are also toxic ingredients, and adverse reactions are sometimes reported

At present, the evaluation of Tripterygium wilfordii mainly focuses on the content determination of the main active ingredient triptolide, but a single chemical component cannot fully reflect the quality of the medicinal material. Although some people have carried out HPLC fingerprint research on the medicinal material Triptolide, However, accurate quantification of each active ingredient in the medicinal material has not been carried out

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